Arnaud Le Rouzic
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arnaudlerouzic.bsky.social
Arnaud Le Rouzic
@arnaudlerouzic.bsky.social
120 followers 130 following 10 posts
CNRS researcher (IDEEV, Université Paris-Saclay, France).

Evolutionary genetics, theoretical quantitative genetics, systems biology.

Associate editor at J. Evol. Biol.

Bridge to my Mastodon account: @arnaudlerouzic.fediscience.org.ap.brid.gy
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arnaudlerouzic.bsky.social
Come and join our team! A 2-year postdoc position is available in our "Genome Evolution" department at Univ Paris Saclay. We want to play with phylogenetic models accounting for horizontal transfers of transposable elements. Application& details on the official portal: emploi.cnrs.fr/Offres/CDD/U...
Object: Postdoc Position Building a phylogenetic model for horizontal transfers of transposable elements A postdoctoral position (24 months) is available to work at EGCE (Gif-sur-Yvette, France, CNRS / Université Paris-Saclay) from January 2026. Transposable elements (TEs) are repetitive DNA sequences capable of promoting their own mobility. They are widespread across the tree of life and often represent a substantial fraction of eukaryotic genomes. Beyond their ability to invade genomes, TEs are frequently reported to undergo horizontal transfer, enabling their colonization of new hosts. However, understanding and predicting how horizontal transfers shape the distribution of TEs among species is far from straightforward. In particular, estimates of transfer rates based on documented cases are both biased and approximate, since transfers occurring close to speciation events are virtually undetectable. This project aims to develop explicit phylogenetic models of TE evolution that incorporate horizontal transfers, and to use these models to obtain statistical estimates of key evolutionary dynamics of TE families across species (e.g., horizontal transfer and extinction rates). The postdoctoral project will focus on exploring the impact of horizontal transfers on the distribution of TE presence/absence among related species, using statistical and/or computational approaches. Context The position will be part of a 4-year collaborative project funded by the French National Agency (ANR). The research consortium gathers two departments (from Paris-Saclay university and from Université Lyon 1), and involves 7 Pls and 5 postdocs and PhD students devoted to distinct workpackages of the project. The postdoc will be based at EGCE, which is part of the Institute for Ecology and Evolution (IDEEV). The institute offers an exciting and active scientific life, it is located on the new research campus of Paris-Saclay, 35 km south of Paris. Relevant references Gilbert C et al. 2018. Horizontal acquisition of transposable elements and viral sequences: patterns and consequences. Cur. Opin. Genet. Dev. 49:15-24. Le Rouzic A et al. 2013. Reconstructing the Evolutionary History of Transposable Elements. Genome Biol. Evol. 5:77-86. Wallau GL et al. 2016. VHICA, a New Method to Discriminate between Vertical and Horizontal Transposon Transfer: Application to the Mariner Family within Drosophila. Mol Biol Evol 33:1094-1109. Profile We are looking for a motivated early career theoretical biologist, with a PhD in theoretical evolutionary biology. Skills in statistics, programming, bio-informatics, and phylogenetic models will be appreciated. Application Formal applications (CV and cover letter) have to be deposited on the CNRS job portal https://emploi.cnrs.fr/Offres/CDD/UMR9191-ARNLER-006/Default.aspx?lang=EN.
September 24, 2025 at 12:26 PM
arnaudlerouzic.bsky.social
Based on simulations, we show that the size and pleiotropy of mutations affecting gene expression heavily depend on the structure of the underlying gene network.
A figure extracted from the scientific paper (https://doi.org/10.1093/evolut/qpaf068). The effect of mutations on fitness depends on the mutation size and the mutation type (Regulatory or Coding mutations). Yet, the network topology (Highly connected, Random, or Scale-free) is a game changer, and conditions which kind of mutation matters the most for fitness.
May 16, 2025 at 1:01 PM
arnaudlerouzic.bsky.social
Very happy to announce the publication of our latest work by my former student Sylvain Pouzet in @journal-evo.bsky.social: "Gene network topology drives the mutational landscape of gene expression".

doi.org/10.1093/evol...

#GeneRegulatoryNetworks
#PopulationGenetics
#EvolutionarySystemsBiology
A theoretical gene regulatory network, featuring 10 genes connected randomly.
May 16, 2025 at 12:58 PM
arnaudlerouzic.bsky.social
Several thousand people today at #standupforscience2025 in Paris.
March 7, 2025 at 7:12 PM