Arda Balci
@ardabalci.bsky.social
Postdoc working on E3 ligases in the context of viral infections. University of Glasgow, CVR based 🧬
Reposted by Arda Balci
Pre-print: our description of RZ affiliate ZNFX1 is now online.
On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution.
Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social
www.biorxiv.org/content/10.1...
On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution.
Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social
www.biorxiv.org/content/10.1...
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA
The detection of viral RNA inside cells triggers a diverse range of antiviral responses, including global translation inhibition, interferon secretion and RNA sequestration. Mutations in the gene ZNFX...
www.biorxiv.org
September 8, 2025 at 1:53 PM
Pre-print: our description of RZ affiliate ZNFX1 is now online.
On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution.
Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social
www.biorxiv.org/content/10.1...
On binding viral RNA, ZNFX1 generates parallel Ub currents, coordinating Ub-dependent RNA silencing and aggregate resolution.
Huge effort from first authors Dan Squair and @eilidhrivers.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Arda Balci
A wee summary of our paper:
Tim and Juraj’s landmark paper from 2020 was the first to elucidate the structural and biochemical detail of RNF213, the largest known E3 and only AAA-E3 hybrid. Among many observations, two stood out: E3 activity was RING-independent and specific for the E2 UBE2L3.
Tim and Juraj’s landmark paper from 2020 was the first to elucidate the structural and biochemical detail of RNF213, the largest known E3 and only AAA-E3 hybrid. Among many observations, two stood out: E3 activity was RING-independent and specific for the E2 UBE2L3.
May 14, 2025 at 11:01 AM
A wee summary of our paper:
Tim and Juraj’s landmark paper from 2020 was the first to elucidate the structural and biochemical detail of RNF213, the largest known E3 and only AAA-E3 hybrid. Among many observations, two stood out: E3 activity was RING-independent and specific for the E2 UBE2L3.
Tim and Juraj’s landmark paper from 2020 was the first to elucidate the structural and biochemical detail of RNF213, the largest known E3 and only AAA-E3 hybrid. Among many observations, two stood out: E3 activity was RING-independent and specific for the E2 UBE2L3.
A labor of love :)
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications
RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...
www.nature.com
May 14, 2025 at 11:39 AM
A labor of love :)
This little tweezer followed me since the first day of my PhD with Stefania Spano. After four brilliant years with the @fletcherlab.bsky.social, it’ll be coming with me to a new chapter! It’ll be weird not to be working on gentle giant #RNF213, but really cool stuff is brewing, so watch this space.
April 10, 2025 at 1:22 PM
This little tweezer followed me since the first day of my PhD with Stefania Spano. After four brilliant years with the @fletcherlab.bsky.social, it’ll be coming with me to a new chapter! It’ll be weird not to be working on gentle giant #RNF213, but really cool stuff is brewing, so watch this space.
Reposted by Arda Balci
It’s a great pleasure to advertise the pre-print of Emma’s OAS2 story!
doi.org/10.1101/2025...
One gene, two transcripts, two antiviral molecules with different virus targets, using different antiviral mechanisms… a great place to release into the community! Well done Emma!
doi.org/10.1101/2025...
One gene, two transcripts, two antiviral molecules with different virus targets, using different antiviral mechanisms… a great place to release into the community! Well done Emma!
Alternative splicing broadens antiviral diversity at the human OAS2 locus
Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provi...
doi.org
March 6, 2025 at 5:33 PM
It’s a great pleasure to advertise the pre-print of Emma’s OAS2 story!
doi.org/10.1101/2025...
One gene, two transcripts, two antiviral molecules with different virus targets, using different antiviral mechanisms… a great place to release into the community! Well done Emma!
doi.org/10.1101/2025...
One gene, two transcripts, two antiviral molecules with different virus targets, using different antiviral mechanisms… a great place to release into the community! Well done Emma!
Is there any way stain nuclear envelope? As in the lipid bilayer of the nucleus not the proteins…
Please retweet to widen the reach :)
Please retweet to widen the reach :)
January 27, 2025 at 12:35 PM
Is there any way stain nuclear envelope? As in the lipid bilayer of the nucleus not the proteins…
Please retweet to widen the reach :)
Please retweet to widen the reach :)
Reposted by Arda Balci
Messages loud & clear: Chris & Alex designed destabilized MS2 and PP7 coat proteins, which are degraded in cells except when bound to their cognate RNA hairpins. We used these probes to image distinct single mRNAs simultaneously in live cells, 'background-free.' AddGene soon! tinyurl.com/27p7hyt9
November 22, 2024 at 3:39 AM
Messages loud & clear: Chris & Alex designed destabilized MS2 and PP7 coat proteins, which are degraded in cells except when bound to their cognate RNA hairpins. We used these probes to image distinct single mRNAs simultaneously in live cells, 'background-free.' AddGene soon! tinyurl.com/27p7hyt9
