www.ahajournals.org/doi/abs/10.1... not directly relevant but in this study from 1960s, increasing furosemide dose increased antihypertensive effect even when diuresis did not increase. Doesn't say infusion has any less effect but does make me wonder

Thanks for sharing. Great to read the actual paper having seen it referenced a few times (usually claiming it supports S-shaped on/off pharmacodynamics). Table 2 is relatable chaos of diuretic prescribing

Measuring BP over a sweater sleeve? As accurate as the optimal method!
But using a non-validated device or leaving the arm unsupported? Expect higher readings than what’s actually seen on awake ABPM.

Underpowered pilot study, so hoping to confirm this in larger trials soon!

2A/ 🚨Our topic from @KIReports: Early determination of Tacrolimus Concentration-Dose ratio identifies risk of allograft loss in kidney transplantation
There are no conflicts of interest. #Medsky #nephsky @theisn.org
www.kireports.org/article/S246...