replaying at the moment, but just can't make "bad" decisions for different endings, I'm too invested

She had better run more naturally than she did in 3! I want to know how the construct the transition from 3 to 4 and the actual gameplay. Witcher 3 is impossible to live up to but I can't wait for 4, but will have to. I really do love the witcher (not netflix, a pox on netflix)

I do agree that Ciri does look and sound different to Witcher 3, Geralt looks very different to witcher 1 which is graphic evolution. I am not sure they have fully captured the Ciri of 3 but worry more on the voice as there is a voice I associate with Ciri

I've also realised just how big it is, the superpower might be the need to wee...

Well it looks like you hook it up to a cannula and infuse it?? Would it give me superpowers?

One final interesting feature, RhF can interfere with other testing
It is in essence a "sticky" antibody and can make it hard to correctly detect cardiolipin, HCV/rubella Abs and some other tests, generally when at very high levels

CCP is maybe more helpful but can still be high in some people and Sjogren's and negatives can miss some cases
One NHS study suggests only 2.8% of RhF tests resulted in a diagnosis of RA
And never forget 10% of RA is seronegative

malignancies and sarcoid amongst other things
It is vital for properly identifying cryoglobulinaemia
So for most people dealing with joint pain, think carefully, this test while sensitive (picks up most RA) is very non specific and throws up lots of false positives

Well not entirely
It's seen in up to 5% of healthy people <50yrs and 25% >70
10% of RA is totally antibody negative
some is only CCP positive
what about other conditions?
seen in up to 20-30% of many CTDs, 40% of infective endocarditis, seen at increased rates in cirrhosis, PBC,

Although some assays say they pick up all isotypes, they don't normally differentiate and IgM tends to predominate
Traditionally done by latex agglutination we now generally use nephlometry/turbidimetry to detect/quantify levels also other methods
And it diagnosis Rheumatoid arthritis right?

Kingdom Come Deliverance, live medieval stuff but until I got the combat it felt awful, once you get it, phenomenal

Witcher 3, just hang out and listening to the music
OK sometimes fighting monsters