Just UK and NA though... 😢

Merci Dr Y 🙏

Grazie Francesco :)

Thanks Vincent!! It's a full noradrenaline-dopamine project, so a lot of fun questions 😉

Grazie Mario!

Despite the translational failure of CRF1 receptor antagonists (see pmc.ncbi.nlm.nih.gov/articles/PMC...), these results show how some of these compounds might find new life in treating opioid-induced social deficits, which are known for worsening the clinical outcome of opioid use disorders.

At last, we show that, in male mice, antalarmin abolishes morphine-induced firing in neurons co-expressing OXY and AVP, but not in neurons expressing only AVP, thereby suggesting a sex-dependent mechanism of action involving CRF1 receptors and oxytocinergic neurons of the PVN.

Then, we replicate these results using the CRF1 genetic mouse model, and show that CRF1 receptor-deficiency prevents morphine-induced sociability deficits and firing of PVN neurons in a gene expression-dependent manner.

In parallel, we show that antalarmin also eliminates morphine-induced firing of PVN neurons in a sex-dependent manner.

First of all, we show that per os administration of the CRF1 receptor antagonist antalarmin completely abolishes sociability deficits induced by morphine, although exclusively in male mice.

Briefly, we investigated whether #CRF1 receptors play a role in the social deficits induced by #morphine and whether they affect the activity of #oxytocin (OXY) and #vasopressin (AVP) -expressing neurons of the paraventricular nucleus of the hypothalamus (#PVN).