Antonio Scialdone
@antonio-scialdone.bsky.social
Group Leader at Helmholtz Munich - single-cell/spatial omics & mathematical modelling of cell fate decision
How can we quantify cell potency from scRNAseq data?
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
Intrinsic dimensionality of single-cell transcriptomic data reveals potency landscapes during cell reprogramming
Cell potency, the ability of a cell to generate other cell types, is a fundamental property that drives development, regeneration, and reprogramming. Recent computational advances have en- abled estim...
www.biorxiv.org
July 25, 2025 at 7:46 PM
How can we quantify cell potency from scRNAseq data?
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
Reposted by Antonio Scialdone
🎤 Apply to speak @our TALENT FORUM by July 31!
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists
🧳Travel+accommodation covered if selected!
📝 Info+how to apply: lnkd.in/drkRvz7N
#postdoc #career #groupleader #HelmholtzMunich #research
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists
🧳Travel+accommodation covered if selected!
📝 Info+how to apply: lnkd.in/drkRvz7N
#postdoc #career #groupleader #HelmholtzMunich #research
July 15, 2025 at 8:24 AM
🎤 Apply to speak @our TALENT FORUM by July 31!
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists
🧳Travel+accommodation covered if selected!
📝 Info+how to apply: lnkd.in/drkRvz7N
#postdoc #career #groupleader #HelmholtzMunich #research
Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists
🧳Travel+accommodation covered if selected!
📝 Info+how to apply: lnkd.in/drkRvz7N
#postdoc #career #groupleader #HelmholtzMunich #research
Reposted by Antonio Scialdone
NEW PAPER ALERT!!
🥚And a new powerful tool for modeling early human development!
@antonio-scialdone.bsky.social ’s lab @www.helmholtz-munich.de & A. Surani’s lab at University Cambridge uncover key insights into early #humandevelopment with 3D human #gastruloids.
Read our news: shorturl.at/7FjGT
🥚And a new powerful tool for modeling early human development!
@antonio-scialdone.bsky.social ’s lab @www.helmholtz-munich.de & A. Surani’s lab at University Cambridge uncover key insights into early #humandevelopment with 3D human #gastruloids.
Read our news: shorturl.at/7FjGT
Here’s our latest study on human gastruloids:
www.science.org/doi/10.1126/...
With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!
www.science.org/doi/10.1126/...
With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!
The emergence of human primordial germ cell–like cells in stem cell–derived gastruloids
3D human gastruloids mimic gastrulation and postgastrulation development, forming the three germ layer derivatives and hPGCLCs.
www.science.org
April 1, 2025 at 12:34 PM
NEW PAPER ALERT!!
🥚And a new powerful tool for modeling early human development!
@antonio-scialdone.bsky.social ’s lab @www.helmholtz-munich.de & A. Surani’s lab at University Cambridge uncover key insights into early #humandevelopment with 3D human #gastruloids.
Read our news: shorturl.at/7FjGT
🥚And a new powerful tool for modeling early human development!
@antonio-scialdone.bsky.social ’s lab @www.helmholtz-munich.de & A. Surani’s lab at University Cambridge uncover key insights into early #humandevelopment with 3D human #gastruloids.
Read our news: shorturl.at/7FjGT
Reposted by Antonio Scialdone
Human #gastruloids as a model for the emergence of #PGCs www.science.org/doi/10.1126/...; early days but it promises as it follows the earlier work of @nmoris.bsky.social on mouse PGCs shorturl.at/FO1p0
The emergence of human primordial germ cell–like cells in stem cell–derived gastruloids
3D human gastruloids mimic gastrulation and postgastrulation development, forming the three germ layer derivatives and hPGCLCs.
www.science.org
March 27, 2025 at 10:51 PM
Human #gastruloids as a model for the emergence of #PGCs www.science.org/doi/10.1126/...; early days but it promises as it follows the earlier work of @nmoris.bsky.social on mouse PGCs shorturl.at/FO1p0
Here’s our latest study on human gastruloids:
www.science.org/doi/10.1126/...
With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!
www.science.org/doi/10.1126/...
With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!
The emergence of human primordial germ cell–like cells in stem cell–derived gastruloids
3D human gastruloids mimic gastrulation and postgastrulation development, forming the three germ layer derivatives and hPGCLCs.
www.science.org
March 27, 2025 at 9:18 AM
Here’s our latest study on human gastruloids:
www.science.org/doi/10.1126/...
With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!
www.science.org/doi/10.1126/...
With the Surani lab, we combine imaging, scRNA-seq and genetic perturbation to investigate the emergence of amnion-&PGC-like cells.
Congrats to Jitesh Neupane, Gabriele Lubatti and all co-authors for their great work!
Why do some cells resist nuclear reprogramming? Using nuclear transfer, we tracked single-cell fate changes in vivo and uncovered cell-type-specific barriers to reprogramming. Suppressing the old identity boosts success!
www.cell.com/stem-cell-re...
www.cell.com/stem-cell-re...
March 13, 2025 at 6:42 PM
Why do some cells resist nuclear reprogramming? Using nuclear transfer, we tracked single-cell fate changes in vivo and uncovered cell-type-specific barriers to reprogramming. Suppressing the old identity boosts success!
www.cell.com/stem-cell-re...
www.cell.com/stem-cell-re...
How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data | Molecular Systems Biology
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
February 12, 2025 at 8:05 PM
How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Join our lab for a summer internship at Helmholtz Munich! Only 1 week left to apply!
🏃♀️🏃ONLY 1 WEEK LEFT!
INTERNSHIP OPPORTUNITY @www.helmholtz-munich.de!
🚀Join 1 of the 7 available teams, gain hands-on experience, and contribute to groundbreaking science on #epigenetics, #AI, #StemCells & more.
Apply: www.helmholtz-munich.de/en/epigeneti...
🗓️ APPLICATION DEADLINE: 17th February
INTERNSHIP OPPORTUNITY @www.helmholtz-munich.de!
🚀Join 1 of the 7 available teams, gain hands-on experience, and contribute to groundbreaking science on #epigenetics, #AI, #StemCells & more.
Apply: www.helmholtz-munich.de/en/epigeneti...
🗓️ APPLICATION DEADLINE: 17th February
February 10, 2025 at 9:52 PM
Join our lab for a summer internship at Helmholtz Munich! Only 1 week left to apply!
Reposted by Antonio Scialdone
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 22, 2025 at 1:56 PM
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
Reposted by Antonio Scialdone
Join us at the next conference on the frontiers between Biological Physics and Statistical Mechanics:
indico.unina.it/event/91/
Contributed talk submission is open.
indico.unina.it/event/91/
Contributed talk submission is open.
Biological Physics and Statistical Mechanics: from molecules to cells and beyond (09-13 giugno 2025)
Overview
The conference on "Biological Physics and Statistical Mechanics" will be held in Napoli, Italy, from June 9 to June 13, 2025.
The meeting aims at bringing together the Italian scientific co...
indico.unina.it
December 8, 2024 at 10:37 AM
Join us at the next conference on the frontiers between Biological Physics and Statistical Mechanics:
indico.unina.it/event/91/
Contributed talk submission is open.
indico.unina.it/event/91/
Contributed talk submission is open.
Reposted by Antonio Scialdone
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...
➡️Register now www.grc.org/histone-and-...
December 8, 2024 at 11:38 AM
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...
➡️Register now www.grc.org/histone-and-...