Antoine Le Gall
@antoinelegall.bsky.social
Biophysicist at CNRS/CBS studying bacterial chromosome secrets, motility, and collective behaviors using multiscale microscopy and bioimage magic.
Reposted by Antoine Le Gall
The qbio #quantitative #biology is part of the IDIL Master program of the Montpellier University.
@umontpellier.bsky.social
idil.edu.umontpellier.fr
@umontpellier.bsky.social
idil.edu.umontpellier.fr
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November 8, 2025 at 11:45 AM
The qbio #quantitative #biology is part of the IDIL Master program of the Montpellier University.
@umontpellier.bsky.social
idil.edu.umontpellier.fr
@umontpellier.bsky.social
idil.edu.umontpellier.fr
🧠 Work by @anna-mas.bsky.social, Tâm Mignot and Marcelo Nollmann
📍 Centre de Biologie Structurale (Montpellier) & Laboratoire de Chimie Bactérienne (Marseille)
🧾 Read the full story www.biorxiv.org/content/10.1...
🧵 6/6
📍 Centre de Biologie Structurale (Montpellier) & Laboratoire de Chimie Bactérienne (Marseille)
🧾 Read the full story www.biorxiv.org/content/10.1...
🧵 6/6
Tunable simultaneous propulsion by two distinct motility motors drives surface motility in bacteria
Motility enables cells to adapt to environmental cues, explore surfaces, and coordinate collective behaviors. Many organisms encode multiple motility systems, but whether these act independently or ca...
www.biorxiv.org
October 31, 2025 at 1:37 PM
🧠 Work by @anna-mas.bsky.social, Tâm Mignot and Marcelo Nollmann
📍 Centre de Biologie Structurale (Montpellier) & Laboratoire de Chimie Bactérienne (Marseille)
🧾 Read the full story www.biorxiv.org/content/10.1...
🧵 6/6
📍 Centre de Biologie Structurale (Montpellier) & Laboratoire de Chimie Bactérienne (Marseille)
🧾 Read the full story www.biorxiv.org/content/10.1...
🧵 6/6
This tunable integration between two motors shows that bacteria can flexibly shift between motility modes, using one, the other, or both as conditions change, reflecting an elegant form of emergent biomechanical coordination. 🧵 5/6
October 31, 2025 at 1:36 PM
This tunable integration between two motors shows that bacteria can flexibly shift between motility modes, using one, the other, or both as conditions change, reflecting an elegant form of emergent biomechanical coordination. 🧵 5/6
Calcium acts as a molecular switch that shifts the balance:
⬇️ Low Ca²⁺ → A-motility dominates (smooth gliding)
⬆️ High Ca²⁺ → S-motility dominates (twitching)
⚖️ Intermediate Ca²⁺ → both cooperate to propel the cell
🎥 Same WT cells, same surface; only [Ca²⁺] changes (50 fps)
⬇️ Low Ca²⁺ → A-motility dominates (smooth gliding)
⬆️ High Ca²⁺ → S-motility dominates (twitching)
⚖️ Intermediate Ca²⁺ → both cooperate to propel the cell
🎥 Same WT cells, same surface; only [Ca²⁺] changes (50 fps)
October 31, 2025 at 1:36 PM
Calcium acts as a molecular switch that shifts the balance:
⬇️ Low Ca²⁺ → A-motility dominates (smooth gliding)
⬆️ High Ca²⁺ → S-motility dominates (twitching)
⚖️ Intermediate Ca²⁺ → both cooperate to propel the cell
🎥 Same WT cells, same surface; only [Ca²⁺] changes (50 fps)
⬇️ Low Ca²⁺ → A-motility dominates (smooth gliding)
⬆️ High Ca²⁺ → S-motility dominates (twitching)
⚖️ Intermediate Ca²⁺ → both cooperate to propel the cell
🎥 Same WT cells, same surface; only [Ca²⁺] changes (50 fps)
Live imaging, single-cell tracking, and modeling show the two motility systems act together in the same cells, producing faster, more versatile motion than either alone.
➡️ Co-propulsion boosts speed and flexibility!
🎥 Left=A-only (50 fps)
🎥 Middle=S-only (50 fps)
🎥 Right=both (WT, 50 fps)
➡️ Co-propulsion boosts speed and flexibility!
🎥 Left=A-only (50 fps)
🎥 Middle=S-only (50 fps)
🎥 Right=both (WT, 50 fps)
October 31, 2025 at 1:34 PM
Live imaging, single-cell tracking, and modeling show the two motility systems act together in the same cells, producing faster, more versatile motion than either alone.
➡️ Co-propulsion boosts speed and flexibility!
🎥 Left=A-only (50 fps)
🎥 Middle=S-only (50 fps)
🎥 Right=both (WT, 50 fps)
➡️ Co-propulsion boosts speed and flexibility!
🎥 Left=A-only (50 fps)
🎥 Middle=S-only (50 fps)
🎥 Right=both (WT, 50 fps)
Many microbes have more than one way to move, but do these systems ever work together?
In M. xanthus, we examined how A-motility (surface adhesions) and S-motility (type IV pili) act together within single cells.
🎥 Left = pili (HILO 25 fps)
🎥 Right = focal adhesions (TIRF 25 fps)
In M. xanthus, we examined how A-motility (surface adhesions) and S-motility (type IV pili) act together within single cells.
🎥 Left = pili (HILO 25 fps)
🎥 Right = focal adhesions (TIRF 25 fps)
October 31, 2025 at 1:28 PM
Many microbes have more than one way to move, but do these systems ever work together?
In M. xanthus, we examined how A-motility (surface adhesions) and S-motility (type IV pili) act together within single cells.
🎥 Left = pili (HILO 25 fps)
🎥 Right = focal adhesions (TIRF 25 fps)
In M. xanthus, we examined how A-motility (surface adhesions) and S-motility (type IV pili) act together within single cells.
🎥 Left = pili (HILO 25 fps)
🎥 Right = focal adhesions (TIRF 25 fps)