Annina Schmid
@anninaschmid.bsky.social
Professor of Pain Neurosciences at Oxford University and Physio at heart:-)
Thanks for having us Mark, always nice to share science! Have a look at this if you are interested in whiplash associated disorder and our recent evidence for nerve pathology and neuropathic pain in some: youtu.be/yip3I689cwU
Whiplash Isn’t Just Neck Pain: What Clinicians Are Missing
YouTube video by Modern Pain Podcast
youtu.be
March 31, 2025 at 10:00 AM
Thanks for having us Mark, always nice to share science! Have a look at this if you are interested in whiplash associated disorder and our recent evidence for nerve pathology and neuropathic pain in some: youtu.be/yip3I689cwU
Thanks Ted, I will forward this to my collaborators🥳
March 7, 2025 at 7:25 AM
Thanks Ted, I will forward this to my collaborators🥳
Cool that these are helpful to you, I will watch out for your publications then!!
March 6, 2025 at 12:11 PM
Cool that these are helpful to you, I will watch out for your publications then!!
and most importantly, a massive thank you to all participants who made this study possible. thank you for your generous time commitment and patience!
@ndcnoxford.bsky.social
@ox.ac.uk
@ndcnoxford.bsky.social
@ox.ac.uk
March 5, 2025 at 8:48 PM
and most importantly, a massive thank you to all participants who made this study possible. thank you for your generous time commitment and patience!
@ndcnoxford.bsky.social
@ox.ac.uk
@ndcnoxford.bsky.social
@ox.ac.uk
A massive thank you again to all co-authors, particularly
Joel Fundaun, Colette Ridehalgh and Andrew Dilley.
Particular thanks to our generous funders
@versusarthritis.bsky.social @medresfdn.bsky.social
Joel Fundaun, Colette Ridehalgh and Andrew Dilley.
Particular thanks to our generous funders
@versusarthritis.bsky.social @medresfdn.bsky.social
March 5, 2025 at 8:48 PM
A massive thank you again to all co-authors, particularly
Joel Fundaun, Colette Ridehalgh and Andrew Dilley.
Particular thanks to our generous funders
@versusarthritis.bsky.social @medresfdn.bsky.social
Joel Fundaun, Colette Ridehalgh and Andrew Dilley.
Particular thanks to our generous funders
@versusarthritis.bsky.social @medresfdn.bsky.social
Overall, our results present a complex phenotypic profile for people with WADII and provide evidence suggestive of peripheral neuroinflammation in a subgroup of individuals.
March 5, 2025 at 8:48 PM
Overall, our results present a complex phenotypic profile for people with WADII and provide evidence suggestive of peripheral neuroinflammation in a subgroup of individuals.
Several serum pro-inflammatory cytokines were raised in people with WADII. So inflammation can be detected systemically. x.com/AnninaBSchmi...
March 5, 2025 at 8:48 PM
Several serum pro-inflammatory cytokines were raised in people with WADII. So inflammation can be detected systemically. x.com/AnninaBSchmi...
Magnetic resonance imaging T2 signal ratio was increased in the C5 root of the brachial plexus and the C5-C8 dorsal root ganglia in WADII participants compared with healthy controls. We did not find changes in the distal median nerve trunk.
March 5, 2025 at 8:48 PM
Magnetic resonance imaging T2 signal ratio was increased in the C5 root of the brachial plexus and the C5-C8 dorsal root ganglia in WADII participants compared with healthy controls. We did not find changes in the distal median nerve trunk.
In the other publication published in
@painthejournal.bsky.social, we focussed on the presence of neuroinflammation in these patients using MRI, serum cytokine evaluation as well as other measures.
journals.lww.com/pain/fulltex...
@painthejournal.bsky.social, we focussed on the presence of neuroinflammation in these patients using MRI, serum cytokine evaluation as well as other measures.
journals.lww.com/pain/fulltex...
Evidence for peripheral neuroinflammation after acute... : PAIN
a subgroup with underlying nerve involvement in WADII, such as peripheral neuroinflammation. This study aimed to investigate the presence of neuroinflammation in acute WADII using T2-weighted magnetic...
journals.lww.com
March 5, 2025 at 8:48 PM
In the other publication published in
@painthejournal.bsky.social, we focussed on the presence of neuroinflammation in these patients using MRI, serum cytokine evaluation as well as other measures.
journals.lww.com/pain/fulltex...
@painthejournal.bsky.social, we focussed on the presence of neuroinflammation in these patients using MRI, serum cytokine evaluation as well as other measures.
journals.lww.com/pain/fulltex...
Multivariable linear regression suggested low-cost bedside tests for hypoaesthesia at the index finger were prognostic for whiplash-related upper quadrant pain 6-months post-injury, however this association was weak.
March 5, 2025 at 8:48 PM
Multivariable linear regression suggested low-cost bedside tests for hypoaesthesia at the index finger were prognostic for whiplash-related upper quadrant pain 6-months post-injury, however this association was weak.
We also took skin biopsies. Intraepidermal nerve fibre densities at the index finger were not significantly different between groups. However, dermal myelinated nerve bundles at the index finger were reduced 6-months post-injury in participants with WADII compared to controls.
March 5, 2025 at 8:48 PM
We also took skin biopsies. Intraepidermal nerve fibre densities at the index finger were not significantly different between groups. However, dermal myelinated nerve bundles at the index finger were reduced 6-months post-injury in participants with WADII compared to controls.
Intriguingly, these functional changes were accompanied by elevated serum neurofilament light chain levels (a marker for axonal damage) acutely after whiplash. This normalised 6 months later. This suggests there is actual structural damage to axons in some people with WADII.
March 5, 2025 at 8:48 PM
Intriguingly, these functional changes were accompanied by elevated serum neurofilament light chain levels (a marker for axonal damage) acutely after whiplash. This normalised 6 months later. This suggests there is actual structural damage to axons in some people with WADII.
QST demonstrated significantly reduced thermal and mechanical detection thresholds in acute WADII compared to controls, some of which persisted at 6 months.
March 5, 2025 at 8:48 PM
QST demonstrated significantly reduced thermal and mechanical detection thresholds in acute WADII compared to controls, some of which persisted at 6 months.
Within 4 weeks of injury, 65% of people with WADII had neuropathic pain which persisted in 32% 6-months post-injury.
March 5, 2025 at 8:48 PM
Within 4 weeks of injury, 65% of people with WADII had neuropathic pain which persisted in 32% 6-months post-injury.
In this @brain1878.bsky.social publication, we demonstrate that people with WADII (traditionally not considered to involve nerve injury) have signs of functional and structural nerve pathology.
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Validate User
academic.oup.com
March 5, 2025 at 8:48 PM
In this @brain1878.bsky.social publication, we demonstrate that people with WADII (traditionally not considered to involve nerve injury) have signs of functional and structural nerve pathology.
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Haha, welcome online Falko! Great to meet you!!!
February 8, 2025 at 1:15 PM
Haha, welcome online Falko! Great to meet you!!!
Agree, super cool!!!
December 11, 2024 at 8:24 AM
Agree, super cool!!!
Wonderful, thank you!!! Still finding my way here 😉
December 4, 2024 at 9:36 PM
Wonderful, thank you!!! Still finding my way here 😉