Anna Pagotto
@annapag.bsky.social
PostDoc in the Picotti Lab @ETHZürich
Reposted by Anna Pagotto
We’re delighted to report a global structural proteome analysis within living cells!
doi.org/10.1038/s443...
#proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social
doi.org/10.1038/s443...
#proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social
January 13, 2026 at 5:29 PM
We’re delighted to report a global structural proteome analysis within living cells!
doi.org/10.1038/s443...
#proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social
doi.org/10.1038/s443...
#proteomics #structuralproteomics #massspectrometry #structuralbiology #ethz @imsb-eth.bsky.social
Reposted by Anna Pagotto
New work out in @commsbio.nature.com @natureportfolio.nature.com! With Anna Pagotto, we show SARS-CoV-2 Mpro has a secondary preference for R↓ beyond LQ↓. This broader specificity can directly activate the coagulation cascade. #Biochem & #Proteomics all in!
www.nature.com/articles/s42... (1/2)
www.nature.com/articles/s42... (1/2)
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...
www.nature.com
August 2, 2025 at 6:53 AM
New work out in @commsbio.nature.com @natureportfolio.nature.com! With Anna Pagotto, we show SARS-CoV-2 Mpro has a secondary preference for R↓ beyond LQ↓. This broader specificity can directly activate the coagulation cascade. #Biochem & #Proteomics all in!
www.nature.com/articles/s42... (1/2)
www.nature.com/articles/s42... (1/2)