Anirudh Wodeyar
@aniwodeyar.bsky.social
Statistics and signal processing for oscillations in the brain.
Assistant Professor at Maastricht University, The Netherlands.
Assistant Professor at Maastricht University, The Netherlands.
For e.g. for patients with epilepsy, stopping seizures stops both the dynamics and clinical symptoms. That's the most drastic example I can think of. (3/3)
November 25, 2025 at 6:32 AM
For e.g. for patients with epilepsy, stopping seizures stops both the dynamics and clinical symptoms. That's the most drastic example I can think of. (3/3)
Think of the canonical example of gamma produced by PING.
So when seen in that light, to me anyway, if we can change oscillations, then we change the overall attractor state of the circuit. If we can do that, then it's inevitable we change function.
(2/3)
So when seen in that light, to me anyway, if we can change oscillations, then we change the overall attractor state of the circuit. If we can do that, then it's inevitable we change function.
(2/3)
November 25, 2025 at 6:32 AM
Think of the canonical example of gamma produced by PING.
So when seen in that light, to me anyway, if we can change oscillations, then we change the overall attractor state of the circuit. If we can do that, then it's inevitable we change function.
(2/3)
So when seen in that light, to me anyway, if we can change oscillations, then we change the overall attractor state of the circuit. If we can do that, then it's inevitable we change function.
(2/3)
You know, thinking of Reviewer 2 as the bear is actually kind of helpful to me psychologically - I see the bear as just trying to make some friends... He _is_ walking away looking awfully lonely at the end.
July 31, 2025 at 8:45 AM
You know, thinking of Reviewer 2 as the bear is actually kind of helpful to me psychologically - I see the bear as just trying to make some friends... He _is_ walking away looking awfully lonely at the end.
At what point do you run home and get under the blanket?
July 31, 2025 at 8:37 AM
At what point do you run home and get under the blanket?
on the same notion but here we see an expansion of that idea.
In the linked post, researchers saw that using tDCS set up perhaps a favorable brain state for a drug effect.
onlinelibrary.wiley.com/doi/10.1002/...
Work from @andreashorn.org and colleagues.
In the linked post, researchers saw that using tDCS set up perhaps a favorable brain state for a drug effect.
onlinelibrary.wiley.com/doi/10.1002/...
Work from @andreashorn.org and colleagues.
Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...
onlinelibrary.wiley.com
July 7, 2025 at 10:18 AM
on the same notion but here we see an expansion of that idea.
In the linked post, researchers saw that using tDCS set up perhaps a favorable brain state for a drug effect.
onlinelibrary.wiley.com/doi/10.1002/...
Work from @andreashorn.org and colleagues.
In the linked post, researchers saw that using tDCS set up perhaps a favorable brain state for a drug effect.
onlinelibrary.wiley.com/doi/10.1002/...
Work from @andreashorn.org and colleagues.
Was just thinking about this paper the other day and how much I enjoyed the way they set up the study. They figured out what brain dynamics were most linked to depressive symptoms, what it took to change that state and used that to implement a closed-loop system. Would love to be pointed to more...
Closed-loop neuromodulation in an individual with treatment-resistant depression - Nature Medicine
This case report describes a biomarker-driven closed-loop therapy for depression using implanted electrodes to continually sense brain activity and automatically trigger direct brain electrical stimul...
www.nature.com
July 3, 2025 at 10:15 AM
Was just thinking about this paper the other day and how much I enjoyed the way they set up the study. They figured out what brain dynamics were most linked to depressive symptoms, what it took to change that state and used that to implement a closed-loop system. Would love to be pointed to more...
That said, developing tools to understanding what is a state (perhaps this is equivalent to an attractor), what are the possible states, tracking states in real-time and assessing what it takes to move from one state to another, is a direction I'm truly excited to engage with.
July 3, 2025 at 10:15 AM
That said, developing tools to understanding what is a state (perhaps this is equivalent to an attractor), what are the possible states, tracking states in real-time and assessing what it takes to move from one state to another, is a direction I'm truly excited to engage with.
My suspicion is that degeneracy (the states possible under one set of parameters vs another can be the same) makes this kind of inference (i.e. assessing whether the system changed or it just received sufficient input to reach a new state) difficult. A classic: www.nature.com/articles/nn1...
Similar network activity from disparate circuit parameters - Nature Neuroscience
Nature Neuroscience - Similar network activity from disparate circuit parameters
www.nature.com
July 3, 2025 at 10:15 AM
My suspicion is that degeneracy (the states possible under one set of parameters vs another can be the same) makes this kind of inference (i.e. assessing whether the system changed or it just received sufficient input to reach a new state) difficult. A classic: www.nature.com/articles/nn1...
See the figure attached below.
The green line and shading represents thalamic spindle coupling in the absence of a coupled thalamic spikes while the orange/red line and shading represents the thalamic spindle coupling in the presence of epileptic spikes.
The green line and shading represents thalamic spindle coupling in the absence of a coupled thalamic spikes while the orange/red line and shading represents the thalamic spindle coupling in the presence of epileptic spikes.
March 18, 2025 at 10:52 AM
See the figure attached below.
The green line and shading represents thalamic spindle coupling in the absence of a coupled thalamic spikes while the orange/red line and shading represents the thalamic spindle coupling in the presence of epileptic spikes.
The green line and shading represents thalamic spindle coupling in the absence of a coupled thalamic spikes while the orange/red line and shading represents the thalamic spindle coupling in the presence of epileptic spikes.