Aniruddha Das
@aniruddhad.bsky.social
Postdoctoral Fellow at University of Texas, Ph.D. in Biochemistry | Interested in Proteostasis Network, Ubiquitin-Proteasome System, Protein Quality Control Pathways, Proteasome Complex
Reposted by Aniruddha Das
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
Loss-of-function mutations in the PINK1 kinase lead to early-onset Parkinson’s disease (PD). PINK1 is activated by mitochondrial damage to phosphorylate ubiquitin and Parkin, triggering mitophagy. PIN...
pmc.ncbi.nlm.nih.gov
May 11, 2025 at 11:48 AM
Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...