Angus Wilson Lab
@anguswilson.bsky.social
Using viruses to explore the fundamentals of molecular and cell biology. Life long obsession with seabirds, shorebirds, ducks and gulls.
Reposted by Angus Wilson Lab
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Checkout our new preprint (www.biorxiv.org/content/10.1...) where we optimize Dorado on RNA from multiple cell types and directly compare to GLORI-seq.
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing
Nanopore direct RNA sequencing (DRS) coupled with Dorado modification-aware basecalling enables mapping of epitranscriptomic modifications including N6-methyladenosine (m6A) at the level of individual...
www.biorxiv.org
November 11, 2025 at 12:35 AM
Checkout our new preprint (www.biorxiv.org/content/10.1...) where we optimize Dorado on RNA from multiple cell types and directly compare to GLORI-seq.
There's a lot of excitement about Dorado, the new modification-aware basecaller from Oxford Nanopore Technologies@nanoporetech.com but the accuracy and best practices are not widely understood.
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing
Nanopore direct RNA sequencing (DRS) coupled with Dorado modification-aware basecalling enables mapping of epitranscriptomic modifications including N6-methyladenosine (m6A) at the level of individual...
www.biorxiv.org
November 11, 2025 at 12:34 AM
There's a lot of excitement about Dorado, the new modification-aware basecaller from Oxford Nanopore Technologies@nanoporetech.com but the accuracy and best practices are not widely understood.
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA: Molecular Cell www.cell.com/molecular-ce...
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA
Cingaram et al. present rPRO-seq, a rapid, low-input technique that enables nascent
transcript profiling from as few as 5,000 cells. Using this method in neurons, they
uncover a crucial role for INTS1...
www.cell.com
August 14, 2025 at 9:37 PM
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA: Molecular Cell www.cell.com/molecular-ce...