Angelo Pugliese
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angelo-rules.bsky.social
Angelo Pugliese
@angelo-rules.bsky.social
Assoc. Director, #compchem 💻, #drugdesign 💊, #digital📱, #ml💡, #ai 🧠. In temporal order: son, Italian, brother, husband, father, British and not much more. Juventus FC. Gym goer. Views my own.
I set up an #agentic #AI workflow inside #VSCode with two free tools.

The "Body" is cline.bot a free, open-source agent for VSCode and the "Brain" is openrouter.ai like a universal remote for #LLMs. It gives you one #API key for hundred of models and many are free.

Works well

#ML #LLM #compchem
Cline - AI Coding, Open Source and Uncompromised
Cline is the open-source AI coding agent that gives you direct access to frontier models with complete transparency. Plan Mode, MCP integration, and zero vendor lock-in. Join 3.8M+ developers.
cline.bot
November 13, 2025 at 9:53 AM
Just back from a working week in Boston, visiting clients and exploring the new frontiers in AI-led drug discovery.
November 8, 2025 at 2:51 PM
🍁🍂🎃 Autumn
October 7, 2025 at 6:24 PM
Great week at the #AIChem25 meeting in Cambridge

Our work on AI-driven design of GLP1 PAMs was very well received
September 27, 2025 at 11:19 AM
I'm looking forward to presenting two posters at #AIChem25

AI-Driven Design of GLP-1R Positive Allosteric Modulators: A Synergy of Generative Models, Active Learning, and Molecular Dynamics

AI-Driven Discovery of Novel NLRP3 Inhibitors Using Reinforcement Learning

#compchem #drugdesign #ml #GLP1
September 15, 2025 at 10:40 AM
Beautiful evening
May 8, 2025 at 8:15 PM
To my network: does anybody have or can redirect me to a Design Of Experiment dataset for ML modelling? Preferably bio/assay data but I can work with anything. It's for a student we are hosting this summer. I checked Google datasets and Kaggle but not much there.
April 26, 2025 at 5:16 PM
I wrote a blog for TheDataLab - Innovation Centre about how hashtag #AI is offering faster, more accurate predictions of a #drug's safety.

#compchem @bioascent.bsky.social
#ml #drugdiscovery #drugdesign #ADMET

thedatalab.com/guest-blog/h...
How AI Makes Finding Safe Medicines Faster - The Data Lab
Discover how AI is transforming drug discovery in this guest blog by Dr. Angelo Pugliese of BioAscent.
thedatalab.com
April 25, 2025 at 10:18 AM
There is always something that you don't know. I didn't know about "Spot GPUs"

GPUs (Graphics Processing Units) that are available for short-term, discounted use in cloud computing platforms, typically through a" spot instance" pricing model.

Thanks Fovus for the chat at #DrugDiscoveryChemistry
April 16, 2025 at 12:25 PM
Our CADD work on KRAS was acknowledged at
#DrugDiscoveryChemisty in San Diego

@bioascent.bsky.social
April 15, 2025 at 9:16 PM
London in the morning mist
April 12, 2025 at 8:16 AM
Nature is waking up
April 6, 2025 at 11:25 AM
April 4, 2025 at 11:41 AM
Where success begins.

Take a tour of our facilities and meet members of our expert team describing the integrated drug discovery offering at BioAscent.

#CompanyVideo #IntegratedDrugDiscovery #LifeSciences #DrugDiscovery
March 27, 2025 at 4:47 PM
March 22, 2025 at 3:25 PM
Not too bad with a normal house oven

#pizzatime
March 15, 2025 at 6:17 PM
Spring is coming?
March 15, 2025 at 3:15 PM
Home office in the sun
March 15, 2025 at 11:16 AM
@elrig.org Research and Innovation 2025, London

A great day of science and innovation ahead

#compchem #drugdesign #drugdiscovery #ai #ml #llm #llms
March 10, 2025 at 9:38 AM
On the hills in southern Italy, my roots
March 4, 2025 at 1:44 PM
Severe weather alert in the UK, straight to the phone. It scared me.

#weather #staysafe
January 23, 2025 at 5:54 PM
January 22, 2025 at 4:47 PM
Me thinking that $500B in 4 years is a lot of money into #AI

#stargate
January 22, 2025 at 1:50 PM
Around Florence
December 21, 2024 at 3:27 PM