Andy Farr
@andydfarr.bsky.social
Reposted by Andy Farr
A repost of a recent post, but this work by @andydfarr.bsky.social, @peteralind.bsky.social and Christina Vasileiou, warrants it! Assaying mutation rates at promoters requires a special set of circumstances. Maybe promoters are generally more mutation-prone, but undetected through lack of assay?
🚨 Bacterial gene promoters mutate faster than expected! 🚨
Scientists found a 5,000-fold mutation rate increase in a bacterial gene promoter, linking it to gene activity—potentially reshaping evolution and antibiotic resistance understanding!
www.evolbio.mpg.de/3810964/news...
#Genetics #Mutation
Scientists found a 5,000-fold mutation rate increase in a bacterial gene promoter, linking it to gene activity—potentially reshaping evolution and antibiotic resistance understanding!
www.evolbio.mpg.de/3810964/news...
#Genetics #Mutation
Extreme Mutation Hotspot in Bacteria Discovered: Study Links High Mutation Rates to Transcriptional Activation
A new study published in PLOS Genetics has identified an extreme mutational hotspot within the genome of Pseudomonas fluorescens, providing unprecedented insight into the relationship between gene reg...
www.evolbio.mpg.de
March 13, 2025 at 12:44 PM
A repost of a recent post, but this work by @andydfarr.bsky.social, @peteralind.bsky.social and Christina Vasileiou, warrants it! Assaying mutation rates at promoters requires a special set of circumstances. Maybe promoters are generally more mutation-prone, but undetected through lack of assay?
Reposted by Andy Farr
Mutation rates vary within genomes.., sure, but: @andydfarr.bsky.social describes a single transcription-dependent C->T mutation in the promoter of rpoS that is ~5,000 times > background. Are promoters places where shit happens, or facilitators of adaptive change? journals.plos.org/plosgenetics...
An extreme mutational hotspot in nlpD depends on transcriptional induction of rpoS
Genetic mutations drive evolution, with effects ranging from harmful to beneficial. While typically considered random, some genomic positions – called “mutational hotspots” – mutate more frequently. H...
journals.plos.org
March 10, 2025 at 2:58 PM
Mutation rates vary within genomes.., sure, but: @andydfarr.bsky.social describes a single transcription-dependent C->T mutation in the promoter of rpoS that is ~5,000 times > background. Are promoters places where shit happens, or facilitators of adaptive change? journals.plos.org/plosgenetics...