@andrush05.bsky.social
www.biorxiv.org/content/10.1...
Excited to share my postdoctoral work! We mapped how loss of FMRP alters excitatory and inhibitory neurons in Fragile X Syndrome (FXS), the leading monogenic cause of autism. Huge molecular divergence — and a new therapeutic target! 🧵
Excited to share my postdoctoral work! We mapped how loss of FMRP alters excitatory and inhibitory neurons in Fragile X Syndrome (FXS), the leading monogenic cause of autism. Huge molecular divergence — and a new therapeutic target! 🧵
Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.
Symptoms of Fragile X Syndrome (FXS), the leading monogenic cause of intellectual disability and autism, are thought to arise from an excitation/inhibition (E/I) imbalance. Here, we leverage cell type...
www.biorxiv.org
April 25, 2025 at 8:54 PM
www.biorxiv.org/content/10.1...
Excited to share my postdoctoral work! We mapped how loss of FMRP alters excitatory and inhibitory neurons in Fragile X Syndrome (FXS), the leading monogenic cause of autism. Huge molecular divergence — and a new therapeutic target! 🧵
Excited to share my postdoctoral work! We mapped how loss of FMRP alters excitatory and inhibitory neurons in Fragile X Syndrome (FXS), the leading monogenic cause of autism. Huge molecular divergence — and a new therapeutic target! 🧵