Andrei Goga
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andreigoga.bsky.social
Andrei Goga
@andreigoga.bsky.social
2.6K followers 1.1K following 110 posts
Professor, UCSF Dept Cell & Tissue Biology and Medicine / Oncology
Breast Medical Oncologist and Cell Biology. Exploring new mechanisms of cancer biology & therapeutics. Views my own. 🧪 #medsky
Oncogenes.net
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andreigoga.bsky.social
Amazing weather in the Bay Area the past week.

Here’s some wildlife spotted in San Francisco over the past few days.

The coyote playing with stuffed animals is a highlight.
Coyote playing with stuffed animal. Cooper’s Hawk on a power line in San Francisco. Great Horned Owl in an oak tree in San Francisco.
November 10, 2025 at 8:28 PM
andreigoga.bsky.social
The UCSF Breast Oncology Program is happy to partner with One More City and founder Christine O’Connell to support metastatic breast cancer research. This will be the 4th year that together with Rapha they have sponsored a century ride.

@ucsfcancer.bsky.social @ctbatucsf.bsky.social
October 25, 2025 at 1:57 AM
andreigoga.bsky.social
Enjoyed the Physics of Life Symposium today @UCSF
September 8, 2025 at 10:03 PM
andreigoga.bsky.social
It’s going down! 🧪
March 7, 2025 at 9:06 PM
andreigoga.bsky.social
If you are in Northern California, consider joining us in San Francisco at City Hall from 1-3 PM this Friday. Outstanding line up of speakers will include: grad students, pharma, astronomers, patients, city supervisors and a Nobel laureate! Please join or help get the word out if you can. 🧪🧬🧫
March 3, 2025 at 10:21 PM
andreigoga.bsky.social
Very important rally this Friday. If you are in Northern California, join us at San Francisco City Hall from 1-3 PM. Outstanding lineup of speakers: grad students, pharma, astronomers, patients, city supervisors and a Nobel laureate. Join or get the word out.

@standupforscience.bsky.social
Sign announcing a rally for science at San Francisco City Hall. Friday, March 7th 1-3PM.
March 3, 2025 at 10:13 PM
andreigoga.bsky.social
Looking forward to the UCSF Breast Oncology Program Retreat tomorrow, including our Session 4 on Tumor Metabolism. Amazing speakers including: Scott Dixon, Kristy Brown, Kai Trepeka, Vivian Lee and Jennifer Rosenbluth
@ucsfcancer.bsky.social @ctbatucsf.bsky.social
February 20, 2025 at 4:44 AM
andreigoga.bsky.social
While taking a walk today, I noticed this fence post.

Hope always survives.
Wooden fencepost with young plants emerging from a hollowed out portion.
February 10, 2025 at 4:03 AM
andreigoga.bsky.social
Congrats Jeremy!

Also, signing the ceiling where the champagne cork landed to celebrate his PhD.
January 18, 2025 at 3:44 AM
andreigoga.bsky.social
Dr. Jeremy Williams presents his thesis studies on lipid metabolism in breast cancer.

Cool story on how TNBC cells and adipocytes are coupled via gap junctions to induce local lipolysis. We propose breast cancers 'steal' lipids for increased FAO and growth.
#metabolism

@ucsfcancer.bsky.social
January 16, 2025 at 5:42 PM
andreigoga.bsky.social
Folks of UCSF reminder today:

Tues Jan 14 3:30-5pm Cole Hall -- Nobel Laureate Carolyn Bertozzi: "Targeting the Glycocalyx for Cancer Immune Therapy" (Zena Werb Memorial Lecture in Cancer Biology

@ucsfcancer.bsky.social
January 14, 2025 at 1:00 PM
andreigoga.bsky.social
Look who I saw on my morning walk. Western Blue Bird, San Francisco
Picture of a Western Blue Bird with orange and blue coloration. San Francisco, CA 1/12/25
January 12, 2025 at 8:43 PM
andreigoga.bsky.social
An excellent talk. A sword, a top hat, and off to Genentech.

I look forward to following all your scientific successes.
December 14, 2024 at 5:55 AM
andreigoga.bsky.social
Join us to celebrate Rachel Nakagawa's thesis defense on Friday the 13th @ctbatucsf.bsky.social @ucsfcancer.bsky.social

Exciting work on how spatial organization of tumors alters emergent properties and therapy response.
December 13, 2024 at 12:06 AM
andreigoga.bsky.social
#Turkeytrot 2024 completed.

Managed to outrun all of the turkeys but few of the humans.
November 27, 2024 at 4:30 PM
andreigoga.bsky.social
Birthday hike along Salt Point State Park, Sonoma Coast, CA
Seals on a rock at Salt Point State Park Waves crashing on a rock.
November 17, 2024 at 5:05 PM
andreigoga.bsky.social
Congratulations to amazing UCSF graduate students Rachel Nakagawa and Jeremy Williams who filed their dissertations this week from the GogaLab.

Really exciting work on functional aspects of tumor spatial organization and metabolism.

@ucsfcancer.bsky.social
@ctbatucsf.bsky.social
The GogaLab at UCSF enjoying lunch on 11/15/2024
November 17, 2024 at 4:59 AM
andreigoga.bsky.social
Amazing grad student Daphne Superville presenting new work from the Goga and Isha Jain labs on how oxygen alters breast metastasis at today’s RIP symposium.

Wouldn’t it be great to use oxygen to prevent and treat breast cancer metastasis? #medsky 🧪

@ucsfcancer.bsky.social
@ctbatucsf.bsky.social
November 16, 2024 at 1:18 AM
andreigoga.bsky.social
Introducing the Goga Lab @ctbatucsf.bsky.social @ucsfcancer.bsky.social

We study aggressive breast and liver cancers and mechanisms of oncogene signaling that lead to metastasis.
Our works spans various areas including metabolism, cell cycle and spatial organization of tumors.

oncogenes.net
Goga Lab members dressed up as characters from The Office (circa October 31, 2023)
November 14, 2024 at 6:11 AM
andreigoga.bsky.social
We model EGFR/RAS/RAF inhibitor sensitivity and resistance. We find inhibitors cause sensitivity in 3D to these agents. In contrast 3D tumor spheres are resistant to DNA damage agent cisplatin.

@ucsfcancer.bsky.social
@ctbatucsf.bsky.social
NSCLC tumor cells are sensitive to EGFR inhibitor afatinib in 3D, but resistant to DNA damaging agent cisplatin. The reverse is true in 2D monolayer.
November 14, 2024 at 5:39 AM
andreigoga.bsky.social
Treatment of NSCLC tumors with EGFR inhibitors causes collapse of the tumor mass, but the tumor remnant includes abundant collagen surrounding the remaining resistant cells both Trichrome and Picrosirius red staining and polarized imaging.

@ucsfcancer.bsky.social
@ctbatucsf.bsky.social
Images of NSCLC tumor xenografts treated with the 2nd generation EGFR inhibitor afatinib. Residual tumor tissues are highly enriched for extracellular matrix, such as collagen.
November 14, 2024 at 5:39 AM
andreigoga.bsky.social
Why do tumor cells become rapidly resistant to EGFR/RAF/RAS inhibitors in lung cancer?

Our latest work from student Rachel Nakagawa identifies that spatial organization of tumor cells can alter YAP localization

Cells grown in 3D have cytoplasmic YAP and readily die.
www.biorxiv.org/content/10.1...
Schema showing how YAP is localize in 2D (nuclear) and 3D (cytoplasmic). Following drug treatment there is more dense matrix allowing for YAP nuclear localization. Figure showing: A. lung tumors shrink by up to 90% after 5 days of afatinib treatment. B.-C. Residual tumor mass shows increased nuclear YAP compared to untreated tumors.
November 12, 2024 at 5:55 AM
andreigoga.bsky.social
Crissy Field, SF today at dusk. One of my favorite places.
November 10, 2024 at 2:15 AM
andreigoga.bsky.social
In Reno today. Strong Kamala Harris vibe. Spoke with many energized young people voting for the first time. Signs of support abound. @kamalahqrepeater.bsky.social

Though dark-horse Rick Astley also there. @rickastl3y.bsky.social
November 3, 2024 at 4:46 AM
andreigoga.bsky.social
Congrats to Tonatiuh (Ton) Montoya who recently defended his PhD from the GogaLab #UCSF (oncogenes.net). Wonderful work revealing that #MYC #livercancer is dependent on alanine catabolism. May lead to new therapies for this deadly disease. @ctbatucsf.bsky.social 🧪
Ton Montoya receiving the ceremonial sword and hat given to PhD recipients The GogaLab at UCSF posing in front of Ton Montoya self-portraits
October 19, 2024 at 4:51 PM