Andreas Horn
@andreashorn.org
Schilling Professor for Computational Neurology at the @netstim.org / University Cologne. Author of @lead-dbs.org & @stimulatingbrains.org
Effect of sliding a cryosectioned brain slice (almost invisible without polarization filters) into a pair of horizontal filters.
November 6, 2025 at 12:40 PM
Effect of sliding a cryosectioned brain slice (almost invisible without polarization filters) into a pair of horizontal filters.
Truly mesmerizing data – and a true honor to see diese heiligen Hallen!
November 6, 2025 at 12:40 PM
Truly mesmerizing data – and a true honor to see diese heiligen Hallen!
Blown away after visiting INM-1 led by Katrin Amunts this Monday – Markus Axer and her showed us their setup of acquiring whole-brain slices (e.g. 7,000 of them to make up Bigbrain 1) – and the mesmerizing effects of polarized light on cryosectioned (raw) brain sections as can be seen in the video.
November 6, 2025 at 12:40 PM
Blown away after visiting INM-1 led by Katrin Amunts this Monday – Markus Axer and her showed us their setup of acquiring whole-brain slices (e.g. 7,000 of them to make up Bigbrain 1) – and the mesmerizing effects of polarized light on cryosectioned (raw) brain sections as can be seen in the video.
Super happy to have one of the official iconic BigBrain trophies on my desk after giving a keynote at the recent HIBALL summit.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
November 6, 2025 at 12:28 PM
Super happy to have one of the official iconic BigBrain trophies on my desk after giving a keynote at the recent HIBALL summit.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
Even though it was a nuisance and led to lots of issues in the BigBrain 1 space, this uniquely skewed brain shape is now iconic and went into the annals of neuroscience.
We made the tract openly available in our Lead-DBS software and its association with OCD symptom relief has been confirmed by a series of independent articles (for a review see: www.biologicalpsychiatryjournal.com/article/S000... ).
October 30, 2025 at 10:26 PM
We made the tract openly available in our Lead-DBS software and its association with OCD symptom relief has been confirmed by a series of independent articles (for a review see: www.biologicalpsychiatryjournal.com/article/S000... ).
Originally, the 'OCD response tract' has been defined in a paper by Ningfei Li et al. (www.nature.com/articles/s41...).
October 30, 2025 at 10:26 PM
Originally, the 'OCD response tract' has been defined in a paper by Ningfei Li et al. (www.nature.com/articles/s41...).
A 26-year-old female with refractory OCD who underwent bilateral ALIC DBS. Initial programming yielded limited benefit for OCD symptoms. Reprogramming based on the 'OCD response tract' led to additional symptom relief.
October 30, 2025 at 10:26 PM
A 26-year-old female with refractory OCD who underwent bilateral ALIC DBS. Initial programming yielded limited benefit for OCD symptoms. Reprogramming based on the 'OCD response tract' led to additional symptom relief.
Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social:
www.biologicalpsychiatryjournal.com/article/S000...
🧵
www.biologicalpsychiatryjournal.com/article/S000...
🧵
October 30, 2025 at 10:26 PM
Nice case report led by Ben Shofty's team adding prospective evidence for tract based reprogramming in deep brain stimulation for obsessive compulsive disorder out in @biologicalpsych.bsky.social:
www.biologicalpsychiatryjournal.com/article/S000...
🧵
www.biologicalpsychiatryjournal.com/article/S000...
🧵
Exciting Sievers lecture by Kamil Uludag ar the HIBALL symposium: what is needed to enable single subject fmri?
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
October 28, 2025 at 9:02 AM
Exciting Sievers lecture by Kamil Uludag ar the HIBALL symposium: what is needed to enable single subject fmri?
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
W shoutout to main developments w LNM @foxmdphd.bsky.social, functional fingerprinting and digital twins.
Of course most exciting for me: cytoarchitectonic proof that the VIM exists (and is not a subunit of VL as implied by the Jones nomenclature).
October 28, 2025 at 8:36 AM
Of course most exciting for me: cytoarchitectonic proof that the VIM exists (and is not a subunit of VL as implied by the Jones nomenclature).
Truly awe-inspiring updates around BigBrain given by Katrin Amunts at the HIBALL closing symposium in Berlin today.
October 28, 2025 at 8:24 AM
Truly awe-inspiring updates around BigBrain given by Katrin Amunts at the HIBALL closing symposium in Berlin today.
Ghostwriting of the finest sense.
October 3, 2025 at 7:11 AM
Ghostwriting of the finest sense.
Anxiosomatic vs dysphoric TMS in a single prospective trial.
October 1, 2025 at 12:01 PM
Anxiosomatic vs dysphoric TMS in a single prospective trial.
Comparison between Jackson Pollock and brain stimulation targeting…
October 1, 2025 at 11:52 AM
Comparison between Jackson Pollock and brain stimulation targeting…
Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!
October 1, 2025 at 11:48 AM
Fantastic talk by Joe Taylor on the „philosophers scan“ and how imaging can help neuromodulation at the Brainclinics TMS Masterclass in Nijmegen!
Still a bit but save the date!
I am excited to be co-organizing so will certainly be there, as well!
I am excited to be co-organizing so will certainly be there, as well!
September 25, 2025 at 2:40 PM
Still a bit but save the date!
I am excited to be co-organizing so will certainly be there, as well!
I am excited to be co-organizing so will certainly be there, as well!
It is clear where I'm going: In the ACT-DBS framework we are proposing, AI-infused adaptive DBS will determine when to stimulate which symptom. Optimization-infused connectomic DBS will determine how to do just that.
September 3, 2025 at 7:59 PM
It is clear where I'm going: In the ACT-DBS framework we are proposing, AI-infused adaptive DBS will determine when to stimulate which symptom. Optimization-infused connectomic DBS will determine how to do just that.
This is a concept termed 'network blending' in a Prog Neurobiol. article by @barbarahollunder.bsky.social.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 3, 2025 at 7:59 PM
This is a concept termed 'network blending' in a Prog Neurobiol. article by @barbarahollunder.bsky.social.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Using algorithms such as Cleartune (also introduced by Nanditha), we are already able to determine optimal stimulation settings for either symptom—or for any combination or blend of symptoms between them.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 3, 2025 at 7:59 PM
Using algorithms such as Cleartune (also introduced by Nanditha), we are already able to determine optimal stimulation settings for either symptom—or for any combination or blend of symptoms between them.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Enter connectomic DBS. @nanditharajamani.bsky.social showed us in her @natcomms.nature.com paper last year that stimulating two specific brain circuits will lead to maximal tremor vs. bradykinesia symptom improvements.
September 3, 2025 at 7:59 PM
Enter connectomic DBS. @nanditharajamani.bsky.social showed us in her @natcomms.nature.com paper last year that stimulating two specific brain circuits will lead to maximal tremor vs. bradykinesia symptom improvements.
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 7:59 PM
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
🙌 Huge congratulations to Clemens Neudorfer – this has been his oevre magnum for the last 3-4 years – and thanks to our fantastic team & collaborators across multiple centers worldwide.
📄 Preprint here: doi.org/10.1101/2025... 
📄 Preprint here: doi.org/10.1101/2025... 
August 22, 2025 at 2:21 PM
🙌 Huge congratulations to Clemens Neudorfer – this has been his oevre magnum for the last 3-4 years – and thanks to our fantastic team & collaborators across multiple centers worldwide.
📄 Preprint here: doi.org/10.1101/2025... 
📄 Preprint here: doi.org/10.1101/2025... 
Clinical translation:
In cohorts of DBS patients (Parkinson’s, dystonia, OCD), symptom improvement correlated with how well stimulation engaged the gene-derived disease network.
Better DBS outcomes = closer match to genetic networks.
In cohorts of DBS patients (Parkinson’s, dystonia, OCD), symptom improvement correlated with how well stimulation engaged the gene-derived disease network.
Better DBS outcomes = closer match to genetic networks.
August 22, 2025 at 2:21 PM
Clinical translation:
In cohorts of DBS patients (Parkinson’s, dystonia, OCD), symptom improvement correlated with how well stimulation engaged the gene-derived disease network.
Better DBS outcomes = closer match to genetic networks.
In cohorts of DBS patients (Parkinson’s, dystonia, OCD), symptom improvement correlated with how well stimulation engaged the gene-derived disease network.
Better DBS outcomes = closer match to genetic networks.