Andrea Arighi
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andrea-arighi.bsky.social
Andrea Arighi
@andrea-arighi.bsky.social
MD, Neurologist at Policlinico of Milan 🇮🇹, Clinical Neuroscientist 🧠: Neurodegenerative dementia, Glymphatic system, Frailty, eHealth
📢 New paper published! We show an association between CSF #Klotho levels and #choroidplexus enlargement in #neurodegenerativediseases, supporting CSF Klotho as a potential biomarker of choroid plexus dysfunction and #brainaging.

👉 Read the paper here: pubmed.ncbi.nlm.nih.gov/41393109/
Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration - PubMed
In this preliminary study, we observed a strong association between CSF Klotho levels and CP enlargement. Reduced CSF Klotho levels, due to CP dysfunction, may contribute to neurodegeneration. If confirmed in larger cohorts, this association suggests that CSF Klotho may serve as a biomarker for CP e …
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 5:48 AM