The title seems higher than the paper.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
November 5, 2025 at 10:43 PM
The title seems higher than the paper.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
They say “show individual nucleoporins” but Fig 1 is just public AlphaFold models.
Typical basket NUPs aren’t even identified.
“We present the AtNPC model” - you can’t model at 35Å.
If you refer to the analysis we did for you, half of the mutations were associated with the rRNA that is folded at the last step on both subunits. So the clustering is around assembly, not function. Probably leading to aberrant assembles, which would have implications when resources are limited.
November 3, 2025 at 11:29 AM
If you refer to the analysis we did for you, half of the mutations were associated with the rRNA that is folded at the last step on both subunits. So the clustering is around assembly, not function. Probably leading to aberrant assembles, which would have implications when resources are limited.
Charting the landscape of cytoskeletal diversity in microbial eukaryotes: Cell www.cell.com/cell/fulltex...
Charting the landscape of cytoskeletal diversity in microbial eukaryotes
An imaging resource of over 200 microbial eukaryotic species provides a glimpse into
the remarkable universe of cytoskeletal diversity.
www.cell.com
October 31, 2025 at 5:45 PM
Charting the landscape of cytoskeletal diversity in microbial eukaryotes: Cell www.cell.com/cell/fulltex...
Could you please post the rest of your sciart figs as well, for those who can't access the publication
October 30, 2025 at 12:52 PM
Could you please post the rest of your sciart figs as well, for those who can't access the publication
Very sad. He was always so lively and encouraging when we met at college dinners. A great teacher for science and life. Deepest condolences.
October 8, 2025 at 10:03 AM
Very sad. He was always so lively and encouraging when we met at college dinners. A great teacher for science and life. Deepest condolences.
"You must take your opponent into a deep dark forest where 2+2 is not 4, and the path out is only wide enough for one.”
- Mikhail Tal
- Mikhail Tal
October 7, 2025 at 1:58 PM
"You must take your opponent into a deep dark forest where 2+2 is not 4, and the path out is only wide enough for one.”
- Mikhail Tal
- Mikhail Tal
The original publication describing the metrics: ‘Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps’ (2025) G. Pintilie, C. Shao, Z. Wang, B. Hudson, J. Flatt, M. Schmid, K. Morris, S. Burley, W. Chiu. Acta Cryst_D81:410-422
Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps
Q-scores are calculated for atomic models derived from 3D electron microscopy maps, measure how well the model fits the map and reflect the quality of the map itself. Here, we develop a statistical mo...
journals.iucr.org
October 1, 2025 at 12:25 AM
The original publication describing the metrics: ‘Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps’ (2025) G. Pintilie, C. Shao, Z. Wang, B. Hudson, J. Flatt, M. Schmid, K. Morris, S. Burley, W. Chiu. Acta Cryst_D81:410-422
He is calling it his ‘last’ ribosome talk… but who believes that
September 7, 2025 at 8:03 PM
He is calling it his ‘last’ ribosome talk… but who believes that
The paper is a masterpiece of modern evolutionary genomics with a potential for synthetic biology. Imagine designing new genes from scratch to improve plant traits.
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...
A de novo-originated gene drives rose scent diversification
Genomic analysis of more than 100 Rosa species uncovers a multi-step process for the
de novo origination of SCREP, a taxon-restricted gene specific to the Rosa genus,
highlighting its function in modu...
www.cell.com
September 3, 2025 at 1:40 AM
The paper is a masterpiece of modern evolutionary genomics with a potential for synthetic biology. Imagine designing new genes from scratch to improve plant traits.
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...
Beautiful work from colleagues at Huazhong Agricultural University in Wuhan.
Link to the paper in Cell: www.cell.com/cell/fulltex...