Kazuaki Amikura
@amikura.bsky.social
Pinned
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
Reposted by Kazuaki Amikura
Structure of the Hibernating Francisella tularensis Ribosome and Mechanistic Insights into Its Inhibition by Antibiotics https://www.biorxiv.org/content/10.1101/2025.11.25.690415v1
November 26, 2025 at 2:33 AM
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
November 24, 2025 at 1:15 PM
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
Reposted by Kazuaki Amikura
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
November 5, 2025 at 1:18 AM
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
Our new preprint is now available! We found a new Group I intron insertion site in tRNA genes of Patescibacteria. These tRNAs were missed by standard tRNA annotation tools. #microbiology #tRNA #Patescibacteria
A Novel Insertion Site for Group I Introns in tRNA Genes of Patescibacteria https://www.biorxiv.org/content/10.1101/2025.07.03.662931v1
July 4, 2025 at 6:43 AM
Our new preprint is now available! We found a new Group I intron insertion site in tRNA genes of Patescibacteria. These tRNAs were missed by standard tRNA annotation tools. #microbiology #tRNA #Patescibacteria
Reposted by Kazuaki Amikura
🎉 Now out “Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free‑living euryarchaeal‑like ancestors” www.nature.com/articles/s41...
Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors - Nature Microbiology
Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.
www.nature.com
June 17, 2025 at 2:25 PM
🎉 Now out “Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free‑living euryarchaeal‑like ancestors” www.nature.com/articles/s41...
Reposted by Kazuaki Amikura
Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...
June 19, 2025 at 7:32 AM
Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...
Reposted by Kazuaki Amikura
"With an apparent inability to live outside its host, and with a genome less than half the size of the previously smallest archaeon genome, Sukunaarchaeum is unlike any other archaeon known." ➡️ www.science.org/content/arti... #MicroSky #Archaea
Microbe with bizarrely tiny genome may be evolving into a virus
With DNA focused almost entirely on replication, newly discovered organism blurs the line between cells and viruses
www.science.org
June 18, 2025 at 6:13 PM
"With an apparent inability to live outside its host, and with a genome less than half the size of the previously smallest archaeon genome, Sukunaarchaeum is unlike any other archaeon known." ➡️ www.science.org/content/arti... #MicroSky #Archaea
Reposted by Kazuaki Amikura
Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
www.nature.com
March 20, 2025 at 10:05 PM
Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...
The binding of RbgA to a critical 50S assembly intermediate facilitates YphC function in bacterial ribosomal assembly
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
The binding of RbgA to a critical 50S assembly intermediate facilitates YphC function in bacterial ribosomal assembly
Abstract. The intricate process of 50S ribosomal subunit assembly in Bacillus subtilis involves multiple parallel pathways converging into a crucial interm
academic.oup.com
December 11, 2024 at 12:11 AM
The binding of RbgA to a critical 50S assembly intermediate facilitates YphC function in bacterial ribosomal assembly
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Kazuaki Amikura
Evolutionary flexibility of ribosome biogenesis in bacteria www.biorxiv.org/content/10.1... #jcampubs
December 2, 2024 at 3:36 PM
Evolutionary flexibility of ribosome biogenesis in bacteria www.biorxiv.org/content/10.1... #jcampubs
Our preprint is now available!🎊🚀
Ribosome biogenesis in CPR bacteria was unexpectedly flexible, challenging traditional view of this essential process in evolution.
#Ribosome #CPR #Evolution
Ribosome biogenesis in CPR bacteria was unexpectedly flexible, challenging traditional view of this essential process in evolution.
#Ribosome #CPR #Evolution
Evolutionary flexibility of ribosome biogenesis in bacteria https://www.biorxiv.org/content/10.1101/2024.11.29.625318v1
Evolutionary flexibility of ribosome biogenesis in bacteria https://www.biorxiv.org/content/10.1101/2024.11.29.625318v1
Ribosomes are essential for protein synthesis and require ribosome biogenesis factors (RBFs) for ass
www.biorxiv.org
December 8, 2024 at 12:19 PM
Our preprint is now available!🎊🚀
Ribosome biogenesis in CPR bacteria was unexpectedly flexible, challenging traditional view of this essential process in evolution.
#Ribosome #CPR #Evolution
Ribosome biogenesis in CPR bacteria was unexpectedly flexible, challenging traditional view of this essential process in evolution.
#Ribosome #CPR #Evolution