Arthur Michaut 🔬🐣
@amichaut.bsky.social
CNRS researcher at Institut Pasteur (J.Gros team) | PhD in O. Pourquié’s lab (Harvard Med School) | ComSciCon France founder | Softbites founder
https://linktr.ee/a_michaut
https://linktr.ee/a_michaut
October 17, 2025 at 9:22 AM
June 3, 2025 at 2:21 PM
We then explored the cellular basis of tissue mechanics. Lowering division frequency (via temperature) or blocking division increased viscosity dramatically (4-fold), demonstrating that cell division is an active epithelial fluidizer.
May 12, 2025 at 2:01 PM
We then explored the cellular basis of tissue mechanics. Lowering division frequency (via temperature) or blocking division increased viscosity dramatically (4-fold), demonstrating that cell division is an active epithelial fluidizer.
We then develop a finite element-based theoretical framework to compute the viscoelastic properties of the early embryo from these mechanical assays.
May 12, 2025 at 2:01 PM
We then develop a finite element-based theoretical framework to compute the viscoelastic properties of the early embryo from these mechanical assays.
The tip of the cantilever consists of a fluorescent bead that contacts the epiblast. Because we know the force necessary to bend the cantilever, we can perform mechanical assays by driving the bead across the embryo and measure in real time the force applied to the tissue.
May 12, 2025 at 2:01 PM
The tip of the cantilever consists of a fluorescent bead that contacts the epiblast. Because we know the force necessary to bend the cantilever, we can perform mechanical assays by driving the bead across the embryo and measure in real time the force applied to the tissue.
In this preprint, I have developed a bespoke motorized cantilever-based manipulator to apply controlled forces within the plane of the early quail epiblast, while concomitantly imaging tissue deformation at a cellular level.
May 12, 2025 at 2:01 PM
In this preprint, I have developed a bespoke motorized cantilever-based manipulator to apply controlled forces within the plane of the early quail epiblast, while concomitantly imaging tissue deformation at a cellular level.
Consequently, the patterned deformation of the epiblast doesn’t depend on the pre-patterning of its mechanical properties, instead, it’s the distribution of forces in the uniformly responding tissue that controls its deformation.
March 13, 2025 at 11:32 AM
Consequently, the patterned deformation of the epiblast doesn’t depend on the pre-patterning of its mechanical properties, instead, it’s the distribution of forces in the uniformly responding tissue that controls its deformation.
This work uncovers an unusual mechanical behavior. Embryonic tissues are classically described as materials with short-time elasticity and long-time viscosity. Here, we show that the elastic and viscous responses co-exist on long morphogenetic timescales within the epithelial embryo.
March 13, 2025 at 11:32 AM
This work uncovers an unusual mechanical behavior. Embryonic tissues are classically described as materials with short-time elasticity and long-time viscosity. Here, we show that the elastic and viscous responses co-exist on long morphogenetic timescales within the epithelial embryo.
This model recapitulates the deformation of the entire epiblast (embryonic + extraembryonic tissues).
March 13, 2025 at 11:32 AM
This model recapitulates the deformation of the entire epiblast (embryonic + extraembryonic tissues).
We showed that this stretching is elastic, as the deformation is reversible, which leads to tension buildup, specifically in the extra-embryonic territory, while it was previously believed that the whole epiblast was under tension
March 13, 2025 at 11:32 AM
We showed that this stretching is elastic, as the deformation is reversible, which leads to tension buildup, specifically in the extra-embryonic territory, while it was previously believed that the whole epiblast was under tension
We then performed high-resolution imaging in the extra-embryonic territory and found that cells extensively increased their apical area by stretching
March 13, 2025 at 11:32 AM
We then performed high-resolution imaging in the extra-embryonic territory and found that cells extensively increased their apical area by stretching
To investigate this process, we quantified the deformation of the embryo over time and showed that area expansion is mostly restricted to the extra-embryonic territory.
March 13, 2025 at 11:32 AM
To investigate this process, we quantified the deformation of the embryo over time and showed that area expansion is mostly restricted to the extra-embryonic territory.
In this paper, we have studied how epiboly takes place in birds, which is the process during which the epithelial extraembryonic tissue expands to engulf the entire yolk.
March 13, 2025 at 11:32 AM
In this paper, we have studied how epiboly takes place in birds, which is the process during which the epithelial extraembryonic tissue expands to engulf the entire yolk.
Grosse mobilisation des Pasteurien-nes avant le départ pour la marche de #StandUpForScienceFrance
En solidarité avec nos collègues aux US (et sur toute le planète) qui voient leur liberté académique entravée ✊
@pasteur.fr @sufs-paris-rp.bsky.social
#StandUpForScience
En solidarité avec nos collègues aux US (et sur toute le planète) qui voient leur liberté académique entravée ✊
@pasteur.fr @sufs-paris-rp.bsky.social
#StandUpForScience
March 7, 2025 at 2:16 PM
Grosse mobilisation des Pasteurien-nes avant le départ pour la marche de #StandUpForScienceFrance
En solidarité avec nos collègues aux US (et sur toute le planète) qui voient leur liberté académique entravée ✊
@pasteur.fr @sufs-paris-rp.bsky.social
#StandUpForScience
En solidarité avec nos collègues aux US (et sur toute le planète) qui voient leur liberté académique entravée ✊
@pasteur.fr @sufs-paris-rp.bsky.social
#StandUpForScience
This can be explained by a reversible stretching of these cells, as columnar cells adopt a squamous morphology during epiboly and revert to their columnar conformation upon laser-induced relaxation.
November 21, 2024 at 12:55 PM
This can be explained by a reversible stretching of these cells, as columnar cells adopt a squamous morphology during epiboly and revert to their columnar conformation upon laser-induced relaxation.
I then performed high-resolution imaging in the extra-embryonic territory and found that cells extensively increased their apical area
November 21, 2024 at 12:54 PM
I then performed high-resolution imaging in the extra-embryonic territory and found that cells extensively increased their apical area
I quantified the deformation of the embryo over time and showed that area expansion is mostly restricted to an annular region in the extra-embryonic territory
November 21, 2024 at 12:53 PM
I quantified the deformation of the embryo over time and showed that area expansion is mostly restricted to an annular region in the extra-embryonic territory
Then, during my postdoc in J. Gros' lab, I studied the expansion of the extraembryonic territory during early embryonic development in quails, which is the process during which the yolk is engulfed
November 21, 2024 at 12:52 PM
Then, during my postdoc in J. Gros' lab, I studied the expansion of the extraembryonic territory during early embryonic development in quails, which is the process during which the yolk is engulfed
With @mongeralab.bsky.social, we could show that a substantial increase in the extra-cellular space drives tissue elongation with little contribution from proliferation.
More details in my previous tweetorial:
x.com/a_michaut/st...
More details in my previous tweetorial:
x.com/a_michaut/st...
November 21, 2024 at 12:51 PM
With @mongeralab.bsky.social, we could show that a substantial increase in the extra-cellular space drives tissue elongation with little contribution from proliferation.
More details in my previous tweetorial:
x.com/a_michaut/st...
More details in my previous tweetorial:
x.com/a_michaut/st...
During my PhD in O. Pourquie's lab at
@harvardmed.bsky.social, I studied how the anteroposterior axis elongates in #chicken embryos 🐣
To do so, I confined in vitro tissue explants and showed they were capable of autonomous elongation, while they are fluid tissues.
@harvardmed.bsky.social, I studied how the anteroposterior axis elongates in #chicken embryos 🐣
To do so, I confined in vitro tissue explants and showed they were capable of autonomous elongation, while they are fluid tissues.
November 21, 2024 at 12:37 PM
During my PhD in O. Pourquie's lab at
@harvardmed.bsky.social, I studied how the anteroposterior axis elongates in #chicken embryos 🐣
To do so, I confined in vitro tissue explants and showed they were capable of autonomous elongation, while they are fluid tissues.
@harvardmed.bsky.social, I studied how the anteroposterior axis elongates in #chicken embryos 🐣
To do so, I confined in vitro tissue explants and showed they were capable of autonomous elongation, while they are fluid tissues.
Post-application resolution
February 14, 2024 at 4:50 PM
Post-application resolution
Here's a little tweetorial about my latest preprint on @biorxiv-devbio.bsky.social
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x.com/a_michaut/st...
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x.com/a_michaut/st...
February 12, 2024 at 5:17 PM
Here's a little tweetorial about my latest preprint on @biorxiv-devbio.bsky.social
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x.com/a_michaut/st...
⤵️
x.com/a_michaut/st...