Merci Dan 🤗🤗 j’ai du prendre de bons plis à quelque part !!

😆 teamwork!

Merci Mathieu! J'ai la chance d'avoir une équipe de feu!

Merci @aparentlab.bsky.social , l'honneur est pour moi! Quel événement ce sera! Merci au CRCQ 2025 de nous donner une belle occasion de se voir @mathieuferron.bsky.social

Thanks a lot Sylvie!

authors.elsevier.com/a/1lbX43vVUP...

💡 Special thanks to @AlexandreMaréchal for inspiring and collaborative discussions on replication stress at every stage of this work!

🙏 Huge thanks to our collaborators: @AlexandreMaréchal, @KyleMMiller, @NitikaTaneja, @JeanYvesMasson, and our institutions @crchuqc @CRC_ULaval @UniversitéLaval @PROTEO.

Mechanistically,
• 53BP1 & RAD18 don’t bind nucleosomes with RNF168-ubiquitinated macroH2A1.2 ;
• macroH2A1.2 blocks their recruitment to certain loci under stress ;
• Disruption of macroH2A1.2 ubiquitination = toxic RAD18 foci ;
• RAD18 buildup at collapsed forks is MUS81 dependent.

This study revealed an unexpected role for histone macroH2A1.2 ubiquitination in preventing replication fork collapse and RAD18-dependent toxicity during prolonged replication stress. When macroH2A1.2 or its ubiquitination is missing, cells become sensitized to specific types of replication stress.

2/2 To learn more about our lab see our homepage: www.ochslab.org
We are an international, multidisciplinary lab focussed on genome stability maintenance & 3D chromatin.
Happy to be contacted with any questions you might have about this job. / Fena