Anastasia Lyulina
@alyulina.github.io
PhD student w/ Benjamin Good and Dmitri Petrov at Stanford University interested in evolutionary dynamics & somatic evolution
alyulina.github.io
alyulina.github.io
These two independent measurements allowed us to estimate both the cost and dominance of pesticide resistance: decline in exposed cages after pesticide removal requires a fitness cost, while persistence at low frequency in unexposed cages suggests low dominance.
November 6, 2025 at 9:51 PM
These two independent measurements allowed us to estimate both the cost and dominance of pesticide resistance: decline in exposed cages after pesticide removal requires a fitness cost, while persistence at low frequency in unexposed cages suggests low dominance.
Simultaneously inferring both parameters is generally difficult, especially for deleterious alleles. In our experiment, however, costly resistant alleles remained low in unexposed cages; in exposed cages, they rose in frequency with pesticide application and began to decline once it was removed.
November 6, 2025 at 9:51 PM
Simultaneously inferring both parameters is generally difficult, especially for deleterious alleles. In our experiment, however, costly resistant alleles remained low in unexposed cages; in exposed cages, they rose in frequency with pesticide application and began to decline once it was removed.
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
November 6, 2025 at 9:51 PM
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
Looking forward to #evolution2025! I will be talking about how time-varying demography and selection shape the site frequency spectrum — Saturday at 4:15 pm, Population Genetics Theory IV. Come say hi if you are around!
June 20, 2025 at 4:17 PM
Looking forward to #evolution2025! I will be talking about how time-varying demography and selection shape the site frequency spectrum — Saturday at 4:15 pm, Population Genetics Theory IV. Come say hi if you are around!
I am glad to see this work in print & on the cover! Read more at academic.oup.com/genetics/article/228/3/iyae145/7747749
November 6, 2024 at 7:02 PM
I am glad to see this work in print & on the cover! Read more at academic.oup.com/genetics/article/228/3/iyae145/7747749
Our analytical results lead to several empirically relevant findings, e.g. that the dependence of homoplasy on the frequencies of the alleles can distinguish the effects of recombination from the confounding effects of recurrent mutation and epistasis.
April 19, 2024 at 6:52 PM
Our analytical results lead to several empirically relevant findings, e.g. that the dependence of homoplasy on the frequencies of the alleles can distinguish the effects of recombination from the confounding effects of recurrent mutation and epistasis.
We derive how these homoplasy measures depend on the rates of recombination and recurrent mutation, the strength of negative selection and genetic drift, and the present-day frequencies of the mutant alleles.
April 19, 2024 at 6:52 PM
We derive how these homoplasy measures depend on the rates of recombination and recurrent mutation, the strength of negative selection and genetic drift, and the present-day frequencies of the mutant alleles.
In this work, we analyze an alternative class of two-locus statistics that quantify the homoplasy produced by recombination. These measures vanish in the absence of recombination and recurrent mutation and approach one in the limit of linkage equilibrium.
April 19, 2024 at 6:52 PM
In this work, we analyze an alternative class of two-locus statistics that quantify the homoplasy produced by recombination. These measures vanish in the absence of recombination and recurrent mutation and approach one in the limit of linkage equilibrium.
Interpreting these decay curves is notoriously difficult since the magnitude of these correlations is shaped by phenomena like epistasis and demography in addition to recombination (e.g. from @nanditagarud.bsky.social et al. – can recombination be behind the fast decay at short distances?).
April 19, 2024 at 6:51 PM
Interpreting these decay curves is notoriously difficult since the magnitude of these correlations is shaped by phenomena like epistasis and demography in addition to recombination (e.g. from @nanditagarud.bsky.social et al. – can recombination be behind the fast decay at short distances?).