Takeaway: even “simple” dietary fibres can ripple across the microbiota–gut–brain axis — and dosage + sex differences matter. 🐟

And it wasn’t the same for everyone:
♀️ High gum Arabic had negative impacts on female reproductive fitness.
♂️ But in males, effects were mostly beneficial.

🐟 Gum Arabic reshaped the gut microbiome (↓ Proteobacteria, ↑ Cetobacterium).
🧠 Changed brain metabolism (↑ acetate at high doses).
🧬 Altered gene expression linked to appetite + energy use.

Thank you, what a cool session!

Thanks 🐠😃

Currently has reference files for zebrafish, medaka and tilapia fish. More species can be added. Full instructions provided if you wish to generate your own species input TE and piRNA files for analysis.