Alistair Forrest
@alforrest.bsky.social
Head of the Systems Biology and Genomics Lab at the Harry Perkins Institute of Medical Research, University of Western Australia
#FANTOM5 #transcriptomics #spatial #cellcommunication #ovariancancer #bioinformatics #singlecell
#FANTOM5 #transcriptomics #spatial #cellcommunication #ovariancancer #bioinformatics #singlecell
To support broader use, we annotated ligand and receptor reagents by species and expanded via orthology to 14 vertebrates.
connectomeDB2025 enables accurate cell–cell communication analysis across model systems and disease contexts. 🌏
connectomeDB2025 enables accurate cell–cell communication analysis across model systems and disease contexts. 🌏
October 31, 2025 at 11:59 PM
To support broader use, we annotated ligand and receptor reagents by species and expanded via orthology to 14 vertebrates.
connectomeDB2025 enables accurate cell–cell communication analysis across model systems and disease contexts. 🌏
connectomeDB2025 enables accurate cell–cell communication analysis across model systems and disease contexts. 🌏
Literature discovery is a major bottleneck. We used PerplexityAI to speed up identification of candidate papers and potential novel ligands/receptors.
Still manually validated ✅ but it helped us find 800+ new supported pairs. And expand the coverage of major L&R gene families
Still manually validated ✅ but it helped us find 800+ new supported pairs. And expand the coverage of major L&R gene families
October 31, 2025 at 11:59 PM
Literature discovery is a major bottleneck. We used PerplexityAI to speed up identification of candidate papers and potential novel ligands/receptors.
Still manually validated ✅ but it helped us find 800+ new supported pairs. And expand the coverage of major L&R gene families
Still manually validated ✅ but it helped us find 800+ new supported pairs. And expand the coverage of major L&R gene families
connectomeDB2025: Quality matters!
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
October 31, 2025 at 11:21 PM
connectomeDB2025: Quality matters!
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
✅3,579 ligand-receptor pairs supported by 2,803 papers
✅14 vertebrates
❌ >2,900 unsupported pairs from other DBs excluded
connectomedb.org
academic.oup.com/nar/advance-...
@JARamilowski @sakura_maezono @rui_hou_ @weitao_lin @yen_yeow + team
Another terrible year for #NHMRC Ideas grants in WA. Only 6 of 127 submissions funded. National rate was 10.1%. If this was an equitable funding scheme WA should have got 12 or 13. Multiple category 6 grants missed out. This means 6 or 7 of the best research groups in WA give up.
December 17, 2024 at 8:16 AM
Another terrible year for #NHMRC Ideas grants in WA. Only 6 of 127 submissions funded. National rate was 10.1%. If this was an equitable funding scheme WA should have got 12 or 13. Multiple category 6 grants missed out. This means 6 or 7 of the best research groups in WA give up.
6th or 7th day of pre new year resolution. Ride to North Cottesloe beach for morning swim. Feeling better for it.
December 27, 2023 at 2:41 AM
6th or 7th day of pre new year resolution. Ride to North Cottesloe beach for morning swim. Feeling better for it.