I’m a fan of this paper from Gillingham that looks at some macrocyclic DELs as a more standard pick (onlinelibrary.wiley.com/doi/full/10....) and this work on a protein-templated DEL system might be an interesting curveball!
www.nature.com/articles/s41...

“Hypervalent iodide giveth and hypervalent iodide taketh away”

Yeah it’s currently cold enough in my building (heater is down) that the dmso spontaneously froze when I started pipetting which 100% didn’t help with my 3mm tube problem

Ooh I might steal this shade of green y’all use…

Wait that’s interesting. Different type of system I think but still very cool. Also I love the phrase “polymer lore”

For an article in the 1970s to specify a reagent was “cautiously added” is really something…

Will update if I can get this route to work 😭

Amazing!! Thank you!!

Hmm wait that makes sense. Ok I might just push the NaN3 route forward and see if adding an external lewis acid gets me similar reactivity in the aggregate. Worst case scenario I make the lithium azide…

Maybe this is a shout into the void but any thoughts on why someone would choose to use lithium azide over sodium azide to ring open an epoxide? Like every lit precedent cites the same original synthetic route and one group even goes about making LiN3 from NaN3. Kinda at a loss

Oh this wasn’t even the example I was thinking of but you just reminded me of a set of papers I saw that “improved” on a lanthanum triflate catalyzed reaction by switching to Pb(NO3)2