Alexander Kwakye
@alexrepgh.bsky.social
Scientist with a focus on population and evolutionary genomics; interested in molecular mechanisms of rapid adaptation.
Reposted by Alexander Kwakye
New paper out in Heredity: 'Evidence of long-term purging of mutation burden in killer whale genomes'. Time calibration of purging was through inclusion of an ancient (7.5Kyr) genome which was close to directly ancestral to the present-day population with signature of purging.
rdcu.be/eM25j
rdcu.be/eM25j
October 28, 2025 at 8:19 AM
New paper out in Heredity: 'Evidence of long-term purging of mutation burden in killer whale genomes'. Time calibration of purging was through inclusion of an ancient (7.5Kyr) genome which was close to directly ancestral to the present-day population with signature of purging.
rdcu.be/eM25j
rdcu.be/eM25j
Reposted by Alexander Kwakye
Experimental rewilding of stickleback drives phenotypic shifts that oppose long-term evolutionary trajectories in Daphnia in Alaskan lakes https://www.biorxiv.org/content/10.1101/2025.10.15.682675v1
October 16, 2025 at 4:32 AM
Experimental rewilding of stickleback drives phenotypic shifts that oppose long-term evolutionary trajectories in Daphnia in Alaskan lakes https://www.biorxiv.org/content/10.1101/2025.10.15.682675v1
Reposted by Alexander Kwakye
Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.10.16.682755v1
October 16, 2025 at 7:32 PM
Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.10.16.682755v1
Reposted by Alexander Kwakye
'Ancient stickleback genomes reveal the early stages of parallel adaptation' - now published online in Evolution @journal-evo.bsky.social
August 15, 2025 at 5:12 AM
'Ancient stickleback genomes reveal the early stages of parallel adaptation' - now published online in Evolution @journal-evo.bsky.social
Reposted by Alexander Kwakye
Ancient stickleback genomes reveal the chronology of parallel adaptation https://www.biorxiv.org/content/10.1101/2025.04.14.648705v1
April 18, 2025 at 8:32 AM
Ancient stickleback genomes reveal the chronology of parallel adaptation https://www.biorxiv.org/content/10.1101/2025.04.14.648705v1
Reposted by Alexander Kwakye
Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback https://www.biorxiv.org/content/10.1101/2025.03.25.642177v1
March 26, 2025 at 4:32 PM
Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback https://www.biorxiv.org/content/10.1101/2025.03.25.642177v1
Reposted by Alexander Kwakye
Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback https://www.biorxiv.org/content/10.1101/2025.03.25.642177v1
March 26, 2025 at 4:32 PM
Rare Jackpot Individuals Drive Rapid Adaptation in Threespine Stickleback https://www.biorxiv.org/content/10.1101/2025.03.25.642177v1
Reposted by Alexander Kwakye
Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure https://www.biorxiv.org/content/10.1101/2025.02.28.640879v1
March 3, 2025 at 6:33 AM
Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure https://www.biorxiv.org/content/10.1101/2025.02.28.640879v1
Reposted by Alexander Kwakye
Blood-based Epigenetic Instability Linked to Human Aging and Disease https://www.biorxiv.org/content/10.1101/2025.02.25.640133v1
March 1, 2025 at 2:32 PM
Blood-based Epigenetic Instability Linked to Human Aging and Disease https://www.biorxiv.org/content/10.1101/2025.02.25.640133v1
Reposted by Alexander Kwakye
Tracing the Spread of Celtic Languages using Ancient Genomics https://www.biorxiv.org/content/10.1101/2025.02.28.640770v1
March 1, 2025 at 11:33 AM
Tracing the Spread of Celtic Languages using Ancient Genomics https://www.biorxiv.org/content/10.1101/2025.02.28.640770v1
Reposted by Alexander Kwakye
Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution https://www.biorxiv.org/content/10.1101/2024.12.29.630632v1
December 30, 2024 at 6:34 AM
Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution https://www.biorxiv.org/content/10.1101/2024.12.29.630632v1
Reposted by Alexander Kwakye
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u
Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network
A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.
scim.ag
February 25, 2025 at 2:25 PM
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u
Reposted by Alexander Kwakye
Estimating gene conversion rates from population data using multi-individual identity by descent https://www.biorxiv.org/content/10.1101/2025.02.22.639693v1
February 27, 2025 at 3:47 PM
Estimating gene conversion rates from population data using multi-individual identity by descent https://www.biorxiv.org/content/10.1101/2025.02.22.639693v1
Reposted by Alexander Kwakye
Accelerated genome shuffling associated with rapid evolution of sexual conflict in seed beetles https://www.biorxiv.org/content/10.1101/2025.02.24.639998v1
February 28, 2025 at 11:37 AM
Accelerated genome shuffling associated with rapid evolution of sexual conflict in seed beetles https://www.biorxiv.org/content/10.1101/2025.02.24.639998v1
Reposted by Alexander Kwakye
Local Adaptation of Life-History Traits in a Seasonal Environment https://www.biorxiv.org/content/10.1101/2025.02.25.640023v1
February 28, 2025 at 11:36 AM
Local Adaptation of Life-History Traits in a Seasonal Environment https://www.biorxiv.org/content/10.1101/2025.02.25.640023v1
Reposted by Alexander Kwakye
Not just mutations: Inbreeding depression persists without genetic variation https://www.biorxiv.org/content/10.1101/2025.02.25.640231v1
February 28, 2025 at 11:34 AM
Not just mutations: Inbreeding depression persists without genetic variation https://www.biorxiv.org/content/10.1101/2025.02.25.640231v1
Reposted by Alexander Kwakye
Variant effects depend on polygenic background: experimental, clinical, and evolutionary implications https://www.biorxiv.org/content/10.1101/2025.01.07.631805v1
January 8, 2025 at 7:33 AM
Variant effects depend on polygenic background: experimental, clinical, and evolutionary implications https://www.biorxiv.org/content/10.1101/2025.01.07.631805v1
Reposted by Alexander Kwakye
Viral Simulation Reveals Overestimation Bias in Within-Host Phylodynamic Migration Rate Estimates Under Selection https://www.biorxiv.org/content/10.1101/2025.01.06.631458v1
January 7, 2025 at 11:31 PM
Viral Simulation Reveals Overestimation Bias in Within-Host Phylodynamic Migration Rate Estimates Under Selection https://www.biorxiv.org/content/10.1101/2025.01.06.631458v1
Happy new year 🎆
January 1, 2025 at 3:04 PM
Happy new year 🎆
I wish Zach Bryan’s Bathwater was much longer. What a beautiful song.
December 31, 2024 at 10:30 PM
I wish Zach Bryan’s Bathwater was much longer. What a beautiful song.
I’ve learned to be measured in all my dealings. It’s helped me to avoid a lot of unnecessary altercations.
December 31, 2024 at 7:37 PM
I’ve learned to be measured in all my dealings. It’s helped me to avoid a lot of unnecessary altercations.