Alex Butters
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alexbutters25.bsky.social
Alex Butters
@alexbutters25.bsky.social
Lab manager and Clinical Researcher, Clinical Genomics Lab, Garvan Institute | PhD in Health Disparities in Genetic Heart Disease & SCD | MPH | Conjoint Associate Lecturer, UNSW Medicine & Health
💡 Sex-specific approaches are key in managing HCM.

Reporting sex-disaggregated data helps address disparities and guide tailored management strategies for better patient care.

Our findings emphasise the importance of understanding sex differences in HCM for improved care and outcomes.
February 24, 2025 at 6:12 AM
📌 Key findings:
✅ Females have a higher risk of heart failure but a lower risk of ventricular arrhythmias (VA) & atrial fibrillation (AF) compared to males.
✅ MYBPC3 variants may protect females from heart failure but not males.
✅ ESC risk scores may underestimate VA risk in females.
February 24, 2025 at 6:12 AM
🔍 We aimed to uncover how clinical and genetic factors contribute to sex differences in HCM outcomes
February 24, 2025 at 6:12 AM
Women with HCM are often diagnosed later and face more severe disease than men, but why? 🤔 The reasons aren’t fully understood. What's clear, though, is that most clinical guidelines for HCM are based on research that predominantly includes male participants.

📖 Related work: bit.ly/41uqyj1
February 24, 2025 at 6:12 AM