Alexandra Teslenko
@alexateslenko.bsky.social
Biochemist, PhD, @LCBM, EPFL🇨🇭
PTMs | ubiquitin | single-molecule enzymology🔬| chromatin | PRC1 mediated gene regulation 🧬
PTMs | ubiquitin | single-molecule enzymology🔬| chromatin | PRC1 mediated gene regulation 🧬
Reposted by Alexandra Teslenko
Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/...
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate the endless work of CTCF in shaping the 3D genome architecture.
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate the endless work of CTCF in shaping the 3D genome architecture.
CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation
Abstract. CTCF binding sites serve as anchors for the 3D chromatin architecture in vertebrates. The functionality of these anchors is influenced by the res
academic.oup.com
July 8, 2025 at 3:30 PM
Excited to share our latest study published in Nucleic Acids Research: academic.oup.com/nar/article/...
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate the endless work of CTCF in shaping the 3D genome architecture.
It’s the cover story for Issue #12! We drew inspiration from Greek mythology to illustrate the endless work of CTCF in shaping the 3D genome architecture.
We are very grateful for the long-time financial support from the @erc.europa.eu, @snsf.ch, and EPFL (EDCH) who made this work possible! 🍀
May 22, 2025 at 11:00 AM
We are very grateful for the long-time financial support from the @erc.europa.eu, @snsf.ch, and EPFL (EDCH) who made this work possible! 🍀
Using single-molecule dynamics, we observe real-time vPRC1 ubiquitylation of the chromatin fibers. vPRC1 dynamically engages chromatin, a process depending on E2 and H2Aub, while its PCGF subunit governs the formation of the catalytically competent complex with E2~Ub and enzymatic processivity.
May 22, 2025 at 11:00 AM
Using single-molecule dynamics, we observe real-time vPRC1 ubiquitylation of the chromatin fibers. vPRC1 dynamically engages chromatin, a process depending on E2 and H2Aub, while its PCGF subunit governs the formation of the catalytically competent complex with E2~Ub and enzymatic processivity.