Alexander Neumann
@alexander-neumann.bsky.social
Epidemiologist studying the (epi-)genetics of child psychiatric problems and child development.
Assistant professor at Erasmus University Medical Center, Rotterdam, the Netherlands.
https://orcid.org/0000-0001-6653-3203
Assistant professor at Erasmus University Medical Center, Rotterdam, the Netherlands.
https://orcid.org/0000-0001-6653-3203
Indeed, getting flooded with review request for 2-sample MR papers. To plays devil's advocate: Maybe it's ok/efficient to pump out mindlessly tons of MR papers as long as methods/results are valid? Many are flawed, but many seem scientifically ok, so maybe does not hurt to have it in the literature?
May 17, 2025 at 12:13 PM
Indeed, getting flooded with review request for 2-sample MR papers. To plays devil's advocate: Maybe it's ok/efficient to pump out mindlessly tons of MR papers as long as methods/results are valid? Many are flawed, but many seem scientifically ok, so maybe does not hurt to have it in the literature?
What surprised me is how little DNA methylation associations correlated between time points. We found more correlations between different outcomes than between time points. However, a limitation is that this may partly reflect tissue differences (cord blood vs peripheral blood).
May 5, 2025 at 10:08 AM
What surprised me is how little DNA methylation associations correlated between time points. We found more correlations between different outcomes than between time points. However, a limitation is that this may partly reflect tissue differences (cord blood vs peripheral blood).
1. DNA methylation was more strongly associated with child health outcomes when both were measured concurrently in childhood.
2. However, the number of significantly associated DNA methylation sites was not necessarily larger, sometimes even higher when DNA methylation was measured at birth!
2. However, the number of significantly associated DNA methylation sites was not necessarily larger, sometimes even higher when DNA methylation was measured at birth!
May 5, 2025 at 10:08 AM
1. DNA methylation was more strongly associated with child health outcomes when both were measured concurrently in childhood.
2. However, the number of significantly associated DNA methylation sites was not necessarily larger, sometimes even higher when DNA methylation was measured at birth!
2. However, the number of significantly associated DNA methylation sites was not necessarily larger, sometimes even higher when DNA methylation was measured at birth!