Alexander Coleman
@alexander-coleman.bsky.social
British/German biologist, biotechnologist & science manager. Grant manager @helmholtzai.bsky.social @www.helmholtz-munich.de. Enjoy science, travelling, sport, fine food & ale!
Reposted by Alexander Coleman
Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...
www.nature.com/articles/s42...
ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism
The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...
www.nature.com
September 2, 2025 at 7:01 PM
Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Alexander Coleman
This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
July 27, 2025 at 6:07 PM
This isn't the crispest image, unfortunately, but getting my mouse intestinal organoid to take on the shape of a mouse (nibbling on a chow pellet?) is my achievement of the week 🤩
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜
p.s. @gobletcellguy.bsky.social: this is the mCherry Muc2...the signal is definitely there 🤜