Specifically, we highlight B cell-mediated, antigen-induced activation of T cells both by direct uptake for presentation on MHC, and by immune complexes formed by antibody-antigen pairs acquired by dendritic cells 8/10

Uniquely, we show that engineered B cells may acquire antigens from tumor cell membranes for presentation to T cells and that antibodies secreted by differentiated engineered B cells induce cytotoxic reactions 6/10

Employing a creative engineering approach, we leverage both isoforms simultaneously to harness a multi-modal therapeutic platform 4/10

When released as a secreted protein, antibodies enable cytotoxic functions as well as immune-complex-mediated antigen presentation following uptake by other antigen-presenting cells 3/10

B(eautiful) cells are antigen-specific-presenting cells. While coded as a receptor, the antibodies they express enable high-affinity internalization of antigens for presentations on MHC molecules to activate T cells 2/10