Aleksandra (Sanya) Anisimova
@alessandrick.bsky.social
PhD student in molecular biology🧑🔬 with great interest in 🧪RNA-binding proteins, ⚗️ ribosome, and 🧬genome-wide approaches
Dog trainer in the evenings and on the weekends 🐾
Dog trainer in the evenings and on the weekends 🐾
4/ 🔬 Mechanistically, we observed increased association of IGF2BP3 with the mRNA decapping complex during ER stress, which can result in enhanced degradation of IGF2BP3 targets
April 7, 2025 at 3:14 PM
4/ 🔬 Mechanistically, we observed increased association of IGF2BP3 with the mRNA decapping complex during ER stress, which can result in enhanced degradation of IGF2BP3 targets
3/📉 By tracking changes in total and newly transcribed mRNAs, we show that IGF2BP3 facilitates UPR via two distinct mechanisms:
• It reduces protein folding load by destabilizing most of its target mRNAs
• It upregulates UPR effectors stabilizing mRNAs encoding select transcriptional regulators
• It reduces protein folding load by destabilizing most of its target mRNAs
• It upregulates UPR effectors stabilizing mRNAs encoding select transcriptional regulators
April 7, 2025 at 3:13 PM
3/📉 By tracking changes in total and newly transcribed mRNAs, we show that IGF2BP3 facilitates UPR via two distinct mechanisms:
• It reduces protein folding load by destabilizing most of its target mRNAs
• It upregulates UPR effectors stabilizing mRNAs encoding select transcriptional regulators
• It reduces protein folding load by destabilizing most of its target mRNAs
• It upregulates UPR effectors stabilizing mRNAs encoding select transcriptional regulators
2/🔬 IGF2BP3 is an RNA-binding protein known for regulating mRNA stability, particularly in development & cancer. Surprisingly, under ER stress, IGF2BP3 binds key UPR effector transcripts including XBP1, HSPA5, and DDIT3 (CHOP) —major regulators of ER stress adaptation & apoptosis
April 7, 2025 at 3:11 PM
2/🔬 IGF2BP3 is an RNA-binding protein known for regulating mRNA stability, particularly in development & cancer. Surprisingly, under ER stress, IGF2BP3 binds key UPR effector transcripts including XBP1, HSPA5, and DDIT3 (CHOP) —major regulators of ER stress adaptation & apoptosis
1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 7, 2025 at 3:10 PM
1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...