Andres Legarra
alegarra.bsky.social
Andres Legarra
@alegarra.bsky.social
things: books, geek, genetics, cattle, ardiak, fromage
langs: Spanish > French \approx English > Italian >> Basque
sites: uscdcb.com; https://alegarra.github.io/
"sic transit gloria mundi"
March 27, 2025 at 12:48 PM
Reposted by Andres Legarra
Also worth reading the reviews of the original article. Obviously these reflect past versions of the article. It would be interesting to read the first submission to see how extreme a position the first submission took.

static-content.springer.com/esm/art%3A10...
static-content.springer.com
January 16, 2025 at 11:41 PM
Reposted by Andres Legarra
As part of a conference on the topic I wrote a commentary on why I was quite pessimistic about this approach, echoing some of the concerns lifted here. The proceedings are online: www.nibjournal.ed.ac.uk/article/view...
The Genetic Architecture of Economically Important Traits Provides Major Challenges for the Implementation of Gene Editing in Livestock | National Institutes of Bioscience Journal
www.nibjournal.ed.ac.uk
January 10, 2025 at 9:02 AM
One reason is that reviewers and editor for journals do a good job. I've seen quite a few preprints (including mine) improve *a lot* and remove mistakes after revision. The same process can catch fraud.
December 15, 2024 at 5:31 PM
quand en France on arretera de penser que la science est fait *que* par des "Pasteur"
November 21, 2024 at 3:53 PM
in one paper we compared "per farm" weights with average weights and genetic gains were nearly identical: doi: 10.1017/S1751731107657814
September 25, 2024 at 4:02 PM
agreed. What one can try is to show that very crude weights are much better than just improving milk or milk+repro or desired gains or whatever
September 25, 2024 at 4:01 PM
you may think in Pythagoras theorem, if you select only for milk you gain 1, if you select only for repro you gain 1, if you select both you gain 0.71 in each of them (or something like that) but 1.41 overall
September 25, 2024 at 3:57 PM
"too many traits" is true in the sense that if you improve 2 traits simultaneously you may have smaller gains in both than improving them alone. But that will make you loose money.
September 25, 2024 at 3:55 PM