Alessandra Carbone
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alecarbone.bsky.social
Alessandra Carbone
@alecarbone.bsky.social
Computational Biology @sorbonneuniversite.bsky.social
- Protein Sequences in Structure/Function/Classification, Genome Structure, Ancient Genomes & Geometry of Logical Reasoning
We connected molecular signatures of selection with their mechanistic and functional relevance opening new ways of guiding experimental assays without requiring exhaustive testing of tens or hundreds of candidates.
Read in Molecular Biology and Evolution: academic.oup.com/mbe/advance-...
September 28, 2025 at 2:33 PM
PRESCOTT online in Genome Biology! see how it works on differentiating mutational effects across isoforms, on unique genetic heritage, recessive and dominant inheritance modes, gain-of-function mutations at link.springer.com/article/10.1....
Work done with M.Tekpinar T.Henry L.David
PRESCOTT: a population aware, epistatic, and structural model accurately predicts missense effects - Genome Biology
Predicting the functional impact of point mutations is a critical challenge in genomics. PRESCOTT reconstructs complete mutational landscapes, identifies mutation-sensitive regions, and categorizes mi...
link.springer.com
May 6, 2025 at 8:09 PM
Designing a functional switch? We recoded a function of Chlamydomonas reinhardtii thioredoxin type-h into a photosynthetic type-f by switching selectivity determinants. Soon out in Frontiers in Plant Science: lnkd.in/emVPNHHa
with Julien Henri, Stephane Lemaire, Gianluca Lombardi and Andrea Mancini.
February 20, 2025 at 7:14 AM
Diversifying disorders by distinguishing intrinsic and soft disorders, improves our understanding of proteins. See our new preprint on "LoRA-DR-suite: adapted embeddings predict intrinsic and soft disorder from protein sequences" - lnkd.in/esSD3qxq work done with Beatriz Seoane and Gianluca Lombardi
February 8, 2025 at 7:49 PM
Postdoc position on Al-Driven Discovery of Next-Gen Antibiotics. Join my team! Please, forward it. hashtag#AI hashtag#MachineLearningandAI hashtag#Artificialintelligence hashtag#MachineLearning hashtag#protein
February 1, 2025 at 10:15 PM