Excellent work, Payam! Congratulations to you and the entire team on this insightful paper!

Thanks to the paper's first author,
@rhodophila
, all our collaborators, and Wellcome and BBSRC, among others, for funding this study.

Finally, it's too early to know if this happens in humans. If it does, early treatment of mitochondrial disease is crucial. If not, we must learn how adult flies cope with minimal CI and apply that knowledge to #humans.

#Omics analysis reveals differences between short- and long-lived individuals. These can be explored to identify which features of CI depletion are pathogenic (found only in short-lived flies) and which are not (found in long-lived flies).

Our results identify development as the critical stage where CI must function optimally, while age-related CI reduction in activity may act as an anti-ageing adaptation.

If we massively reduce CI levels only in adult flies, they do not live shorter but instead live longer than controls. Notably, this depletion exceeds the levels observed in aged flies and is comparable to the reduction seen in individuals suffering from #mitochondrialdisease.

During development, a small disruption of mitochondrial #ComplexI (CI) in #Drosophila enormously shortens adult lifespan. This disruption falls within the natural variability in mitochondrial respiration observed among wild-type strains.