8/8
It would have been enriching, collaborative and collegial to reach out for clarification or additional details.
The full study can be read here: pmc.ncbi.nlm.nih.gov/articles/PMC...

7/
On one hand, these results highlight the importance of analyzing both the linear and nonlinear association between PA and health phenotypes. On the other hand, given the unexpected nonlinear pattern, we cannot discard the possibility of FP findings; this should be validated in other studies.”

6/
... previous studies focused on clinical phenotypes such as CHD risk, in which low levels of PA were associated with CHD risk reduction, but at higher levels of PA, risk reduction tended to reach a plateau (39). However, in our results, only high levels of MVPA were associated with DNAm patterns.

5/
... differential methylation in association with PA, specifically MVPA. The analysis of the dose–response pattern suggests a nonlinear relationship between PA and methylation levels of the reported CpG. The nonlinear dose–response relationship between DNA methylation and PA is consistent with...

4/
... using generalized additive models. That’s why we did not run a standard meta-analysis for the nonlinear associations and instead combined P values following a rigorous two-stage replication framework.
As written in the discussion: “In this two-stage EWAS, we found two CpG sites showing...

3/
... I would have thought such misrepresentations may stem from downloading summary statistics from a simplistic, biased catalog, but ours aren’t even there precisely because there are no effect sizes for the nonlinear analyses that yielded positive results, which focused on dose–response patterns

2/
... from 3 independent samples; 619/1,735/190) being misrepresented in a recent EWAS of wearable-measured physical activity in a cross-ancestry sample of 353 pregnant women in Oslo. This suggests that our paper (old by now - it is from my PhD) was not actually read.

Thank you all for making this possible by supporting us in giving him the chance to survive, and overcome such an unfortunate episode. Thank you so much for showing up for us. You will always find a good homemade tortilla or a PB paella at ours.
Ref: www.gofundme.com/f/help-save-...
3/3

On 10/07/16, Trasno was exploring the place that would be his home for nearly 4 years, after his first night as Trasno Fernández Ortiz de Guinea.
Fast forward to 10/07/25, he had his surgery check-up, received the results on his condition, and showed an impressive improvement in his recovery.
2/