Anna-Karina Felder
@akfelder.bsky.social
PhD Student in the deLaatLab
at the @Hubercht institute, investigating enhancer functions in complex regulatory landscapes.
at the @Hubercht institute, investigating enhancer functions in complex regulatory landscapes.
Proud of the work accomplished as part of my PhD project and deeply grateful for the incredible collaboration behind it. This wouldn’t have been possible without the amazing team — huge thanks to everyone involved!
#WorldSickleCellDay #Gratitude #PhDJourney #SickleCellAwareness
#WorldSickleCellDay #Gratitude #PhDJourney #SickleCellAwareness
On 🌎World Sickle Cell Day🩸 we share a new gene therapy approach that holds promise for patients with sickle cell disease, thalassemia and possibly other genetic diseases.🧬 Researchers from the Hubrecht Institute, Erasmus MC, Sanquin and Oncode found a new method to switch genes on.
June 19, 2025 at 1:00 PM
Proud of the work accomplished as part of my PhD project and deeply grateful for the incredible collaboration behind it. This wouldn’t have been possible without the amazing team — huge thanks to everyone involved!
#WorldSickleCellDay #Gratitude #PhDJourney #SickleCellAwareness
#WorldSickleCellDay #Gratitude #PhDJourney #SickleCellAwareness
Reposted by Anna-Karina Felder
What do long-range enhancers need to regulate genes? Researchers from the De Laat group have found that long-range enhancers require optimal regulatory protein levels, in addition to the specific protein complex cohesin, to switch on genes.
Read more here: www.hubrecht.eu/long-range-e...
Read more here: www.hubrecht.eu/long-range-e...
Long-range enhancers more sensitive to regulatory proteins than short-range enhancers
Genes regulated by long-range enhancers are more sensitive to disturbances of regulatory protein levels than those regulated by short-range enhancers.
www.hubrecht.eu
February 25, 2025 at 4:20 PM
What do long-range enhancers need to regulate genes? Researchers from the De Laat group have found that long-range enhancers require optimal regulatory protein levels, in addition to the specific protein complex cohesin, to switch on genes.
Read more here: www.hubrecht.eu/long-range-e...
Read more here: www.hubrecht.eu/long-range-e...
🚨 Preprint finally out! 🚨
Excited to share our latest work showing that linear enhancer-promoter distance matters! 🧬
Big thank you to all the co-authors and everyone who contributed! 🙌
Check it out here: www.biorxiv.org/content/10.1...
#Enhancers #GeneRegulation #Preprint
Excited to share our latest work showing that linear enhancer-promoter distance matters! 🧬
Big thank you to all the co-authors and everyone who contributed! 🙌
Check it out here: www.biorxiv.org/content/10.1...
#Enhancers #GeneRegulation #Preprint
www.biorxiv.org
January 17, 2025 at 12:07 PM
🚨 Preprint finally out! 🚨
Excited to share our latest work showing that linear enhancer-promoter distance matters! 🧬
Big thank you to all the co-authors and everyone who contributed! 🙌
Check it out here: www.biorxiv.org/content/10.1...
#Enhancers #GeneRegulation #Preprint
Excited to share our latest work showing that linear enhancer-promoter distance matters! 🧬
Big thank you to all the co-authors and everyone who contributed! 🙌
Check it out here: www.biorxiv.org/content/10.1...
#Enhancers #GeneRegulation #Preprint