AJ Lees
@ajlees.bsky.social
Professor of Neurology, National Hospital Queen Square, Institute of Neurology, UCL
Writer, Rare Soul,
Writer, Rare Soul,
‘Among all the friendships I have made in life those of school and childish acquaintance are the sweetest- there is no deseption(sic) in them… there is nothing to regret in them but the loss’
@yerwha @JohnClarePoetry @JohnClareSoc
@yerwha @JohnClarePoetry @JohnClareSoc
November 16, 2025 at 10:14 AM
‘Among all the friendships I have made in life those of school and childish acquaintance are the sweetest- there is no deseption(sic) in them… there is nothing to regret in them but the loss’
@yerwha @JohnClarePoetry @JohnClareSoc
@yerwha @JohnClarePoetry @JohnClareSoc
My first published paper and one im very proud of a single author case report
October 28, 2025 at 9:58 AM
My first published paper and one im very proud of a single author case report
Wake up Bluesky and let's have some serious intellectual interactions. It is still like a seance where the spirit never arrives.
A repository for ignored letters and self satisfied publication
A repository for ignored letters and self satisfied publication
October 25, 2025 at 8:42 AM
Wake up Bluesky and let's have some serious intellectual interactions. It is still like a seance where the spirit never arrives.
A repository for ignored letters and self satisfied publication
A repository for ignored letters and self satisfied publication
'"The London, in the East End wasn't a posh hospital. They were waiting for benefactors who had to be begged!...it was written on all the doors that they were waiting for them, and urgently...in pleading terms! The philanthropists took their time"
#Guignolsband
@gavingiovannoni.bsky.social
#Guignolsband
@gavingiovannoni.bsky.social
October 25, 2025 at 8:39 AM
'"The London, in the East End wasn't a posh hospital. They were waiting for benefactors who had to be begged!...it was written on all the doors that they were waiting for them, and urgently...in pleading terms! The philanthropists took their time"
#Guignolsband
@gavingiovannoni.bsky.social
#Guignolsband
@gavingiovannoni.bsky.social
I am reading Céline in French, which is testing, but fun. I have come across a long description of the London Hospital, Whitechapel, extracts from which I will post in the coming days
#LouisFerdinandDestouches #Guignolsband
@gavingiovannoni.bsky.social
#RoyalLondonHospital
#LouisFerdinandDestouches #Guignolsband
@gavingiovannoni.bsky.social
#RoyalLondonHospital
October 25, 2025 at 8:26 AM
I am reading Céline in French, which is testing, but fun. I have come across a long description of the London Hospital, Whitechapel, extracts from which I will post in the coming days
#LouisFerdinandDestouches #Guignolsband
@gavingiovannoni.bsky.social
#RoyalLondonHospital
#LouisFerdinandDestouches #Guignolsband
@gavingiovannoni.bsky.social
#RoyalLondonHospital
Reposted by AJ Lees
Proposing three principles to guide #Parkinson research:
1. Quantify monomeric & pathological α-synuclein
2. Prioritize human evidence over animal models
3. Use clinical trials to test hypotheses, not just molecules
@ajlees.bsky.social
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
1. Quantify monomeric & pathological α-synuclein
2. Prioritize human evidence over animal models
3. Use clinical trials to test hypotheses, not just molecules
@ajlees.bsky.social
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Beyond Pathology: α‐Synuclein Homeostasis and Three Principles to Guide Research
Click on the article title to read more.
movementdisorders.onlinelibrary.wiley.com
October 16, 2025 at 3:50 AM
Proposing three principles to guide #Parkinson research:
1. Quantify monomeric & pathological α-synuclein
2. Prioritize human evidence over animal models
3. Use clinical trials to test hypotheses, not just molecules
@ajlees.bsky.social
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
1. Quantify monomeric & pathological α-synuclein
2. Prioritize human evidence over animal models
3. Use clinical trials to test hypotheses, not just molecules
@ajlees.bsky.social
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
The damage done to the quality of the medical interview by telehealth, electronic health records and mobile phones is immeasurable. Even if accurate information gathering survives
it ruins the communion.
it ruins the communion.
October 11, 2025 at 11:45 AM
The damage done to the quality of the medical interview by telehealth, electronic health records and mobile phones is immeasurable. Even if accurate information gathering survives
it ruins the communion.
it ruins the communion.
At last some good news for democracy. Brazil is more democratic and less corrupt than the United States. It also has a much more sophisticated electoral voting system.
Viva Lula
Viva Lula
September 12, 2025 at 10:02 AM
At last some good news for democracy. Brazil is more democratic and less corrupt than the United States. It also has a much more sophisticated electoral voting system.
Viva Lula
Viva Lula
Pappworth told us when presenting a neurological case offer up what we had deduced in a 3 stage answer
Start with the anatomical site which often begged the next question, what path process? eg neoplastic,
Then the denouement ‘what would you think the likely cause’ glioma
Start with the anatomical site which often begged the next question, what path process? eg neoplastic,
Then the denouement ‘what would you think the likely cause’ glioma
September 9, 2025 at 8:01 AM
Pappworth told us when presenting a neurological case offer up what we had deduced in a 3 stage answer
Start with the anatomical site which often begged the next question, what path process? eg neoplastic,
Then the denouement ‘what would you think the likely cause’ glioma
Start with the anatomical site which often begged the next question, what path process? eg neoplastic,
Then the denouement ‘what would you think the likely cause’ glioma
Precision medicine means to me taking a medical history and performing a neurological examination. It is personalised and always informative.
It also guides my choice of ancillary tests.
It also guides my choice of ancillary tests.
September 4, 2025 at 7:24 AM
Precision medicine means to me taking a medical history and performing a neurological examination. It is personalised and always informative.
It also guides my choice of ancillary tests.
It also guides my choice of ancillary tests.
Another Pappworth tattooed on my brain
‘History recording should never be a stereotyped performance but should be evolved like a well written edited narrative with literary form and style’
‘History recording should never be a stereotyped performance but should be evolved like a well written edited narrative with literary form and style’
August 28, 2025 at 7:22 AM
Another Pappworth tattooed on my brain
‘History recording should never be a stereotyped performance but should be evolved like a well written edited narrative with literary form and style’
‘History recording should never be a stereotyped performance but should be evolved like a well written edited narrative with literary form and style’
I find Bluesky like blowing a horn alone in my front room for my own pleasure. Where is the sparky cut and thrust and disagreement?
July 15, 2025 at 11:45 AM
I find Bluesky like blowing a horn alone in my front room for my own pleasure. Where is the sparky cut and thrust and disagreement?
Sargant is a monster: Laing is a saint.
No nuance, no context
The tragedy of whiggishness in psychiatry and universities
@MikeJayNet @rcpsychNeuro @The_BNPA @Lit_Review
No nuance, no context
The tragedy of whiggishness in psychiatry and universities
@MikeJayNet @rcpsychNeuro @The_BNPA @Lit_Review
July 12, 2025 at 1:01 PM
Sargant is a monster: Laing is a saint.
No nuance, no context
The tragedy of whiggishness in psychiatry and universities
@MikeJayNet @rcpsychNeuro @The_BNPA @Lit_Review
No nuance, no context
The tragedy of whiggishness in psychiatry and universities
@MikeJayNet @rcpsychNeuro @The_BNPA @Lit_Review
The condemnation of Jean-Martin Charcot for one aspect of his multifaceted work, which posterity disapproves of needs to stop. The presentist critics behave as if medical practice, culture and ethics, do not evolve. They lack sensitivity and choose to ignore context
#CharcotBicentenaireParis
#CharcotBicentenaireParis
July 5, 2025 at 12:12 PM
The condemnation of Jean-Martin Charcot for one aspect of his multifaceted work, which posterity disapproves of needs to stop. The presentist critics behave as if medical practice, culture and ethics, do not evolve. They lack sensitivity and choose to ignore context
#CharcotBicentenaireParis
#CharcotBicentenaireParis
FND signs a cautionary note from @jonstoneneuro.bsky.social
June 11, 2025 at 7:29 AM
FND signs a cautionary note from @jonstoneneuro.bsky.social
Perhaps another way to express it is that
The Menu is not the meal
The map is not the territory
The patient is not the measurement
Scientists need to embrace both common sense and nonsense
The Menu is not the meal
The map is not the territory
The patient is not the measurement
Scientists need to embrace both common sense and nonsense
June 10, 2025 at 8:35 AM
Perhaps another way to express it is that
The Menu is not the meal
The map is not the territory
The patient is not the measurement
Scientists need to embrace both common sense and nonsense
The Menu is not the meal
The map is not the territory
The patient is not the measurement
Scientists need to embrace both common sense and nonsense
Some scholars have become so preoccupied with turning reality into definitions that they have totally lost sight of what Parkinson’s disease and Alzheimer’s disease actually are.
They are so fixated with galaxies they can no longer see the stars
They are so fixated with galaxies they can no longer see the stars
June 10, 2025 at 8:35 AM
Some scholars have become so preoccupied with turning reality into definitions that they have totally lost sight of what Parkinson’s disease and Alzheimer’s disease actually are.
They are so fixated with galaxies they can no longer see the stars
They are so fixated with galaxies they can no longer see the stars
There is no such entity as academic medicine. There are doctors paid by universities and others paid by governments or through private practice but we all should be enthusiastic teachers of our craft to the next generations of apprentices
May 31, 2025 at 9:08 AM
There is no such entity as academic medicine. There are doctors paid by universities and others paid by governments or through private practice but we all should be enthusiastic teachers of our craft to the next generations of apprentices
Any soulful neurologists out there in the blue sky?
May 22, 2025 at 9:42 AM
Any soulful neurologists out there in the blue sky?
Bar Italia today
The souvenirs of an Italian Soho coffee house thriving on Froth Street.Through the glass darkly
The modernists are back.
@TheBaristas
@Tim_R_Nicholson @RichardSearling
@AnaZumaR @LondonBookBoy
#Northernsoul
The souvenirs of an Italian Soho coffee house thriving on Froth Street.Through the glass darkly
The modernists are back.
@TheBaristas
@Tim_R_Nicholson @RichardSearling
@AnaZumaR @LondonBookBoy
#Northernsoul
May 22, 2025 at 9:33 AM
Bar Italia today
The souvenirs of an Italian Soho coffee house thriving on Froth Street.Through the glass darkly
The modernists are back.
@TheBaristas
@Tim_R_Nicholson @RichardSearling
@AnaZumaR @LondonBookBoy
#Northernsoul
The souvenirs of an Italian Soho coffee house thriving on Froth Street.Through the glass darkly
The modernists are back.
@TheBaristas
@Tim_R_Nicholson @RichardSearling
@AnaZumaR @LondonBookBoy
#Northernsoul
Dice @ajlees.bsky.social en este artículo que les comparto: "Gabriel García Márquez: the greatest of the amnesia writers", a lo que habría que añadir: "atrapado por la amnesia".
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Gabriel Garcia Marquez, the greatest of the amnesia writers
Andrew Lees looks back at the writings of Gabriel García Márquez, and considers what works such as One Hundred Years of Solitude and The Autumn of the Patr
academic.oup.com
May 4, 2025 at 12:17 PM
Reposted by AJ Lees
Dice @ajlees.bsky.social en este artículo que les comparto: "Gabriel García Márquez: the greatest of the amnesia writers", a lo que habría que añadir: "atrapado por la amnesia".
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
Gabriel Garcia Marquez, the greatest of the amnesia writers
Andrew Lees looks back at the writings of Gabriel García Márquez, and considers what works such as One Hundred Years of Solitude and The Autumn of the Patr
academic.oup.com
April 17, 2025 at 12:04 PM
Dice @ajlees.bsky.social en este artículo que les comparto: "Gabriel García Márquez: the greatest of the amnesia writers", a lo que habría que añadir: "atrapado por la amnesia".
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
I keep hoping BlueSky will fire up but for now it is hard work with negligible feed back at least in neurology
April 12, 2025 at 6:06 PM
I keep hoping BlueSky will fire up but for now it is hard work with negligible feed back at least in neurology