Aize Pellón Rodríguez
@aizepellon.bsky.social
#MSCA Postdoctoral Fellow at CIC bioGUNE (Bilbao, Spain) || Host-microbe interactions || Fungal Immunology || Innate immune memory || Trained immunity || Immunometabolism || Microbiota
#SinCienciaNoHayFuturo #MycoSky
https://linktr.ee/aizepellonrodriguez
#SinCienciaNoHayFuturo #MycoSky
https://linktr.ee/aizepellonrodriguez
Kudos to all co-authors and collaborators! Especially to Sam Pasco and Juan Anguita for leading this project.
@cicbiogune.bsky.social @neikerbrta.bsky.social
🧵6/6
@cicbiogune.bsky.social @neikerbrta.bsky.social
🧵6/6
October 2, 2025 at 3:36 PM
Kudos to all co-authors and collaborators! Especially to Sam Pasco and Juan Anguita for leading this project.
@cicbiogune.bsky.social @neikerbrta.bsky.social
🧵6/6
@cicbiogune.bsky.social @neikerbrta.bsky.social
🧵6/6
🔚 Bottom line:
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.
Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
🧵5/6
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.
Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
🧵5/6
Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow-derived innate cells, e...
doi.org
October 2, 2025 at 3:36 PM
🔚 Bottom line:
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.
Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
🧵5/6
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.
Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
🧵5/6
📊 Bone marrow single-cell transcriptomic (scRNAseq) analyses revealed:
-Upregulation of immune genes (e.g. Elane, Gzmb, Fc receptors)
-Downregulation of epigenetic regulators and metabolic genes
→ A shift toward immune activation and metabolic rewiring.
#RNAseq #Immunometabolism
🧵4/6
-Upregulation of immune genes (e.g. Elane, Gzmb, Fc receptors)
-Downregulation of epigenetic regulators and metabolic genes
→ A shift toward immune activation and metabolic rewiring.
#RNAseq #Immunometabolism
🧵4/6
October 2, 2025 at 3:36 PM
📊 Bone marrow single-cell transcriptomic (scRNAseq) analyses revealed:
-Upregulation of immune genes (e.g. Elane, Gzmb, Fc receptors)
-Downregulation of epigenetic regulators and metabolic genes
→ A shift toward immune activation and metabolic rewiring.
#RNAseq #Immunometabolism
🧵4/6
-Upregulation of immune genes (e.g. Elane, Gzmb, Fc receptors)
-Downregulation of epigenetic regulators and metabolic genes
→ A shift toward immune activation and metabolic rewiring.
#RNAseq #Immunometabolism
🧵4/6
🧬 SAS-trained mice showed:
-Reduced proinflammatory TNF production by macrophages
-Increased circulating monocytes and altered HSPC population dynamics
-Enhanced neutrophil antimicrobial activity
This suggests functional reprogramming of innate cells.
#Macrophages #Neutrophils
🧵3/6
-Reduced proinflammatory TNF production by macrophages
-Increased circulating monocytes and altered HSPC population dynamics
-Enhanced neutrophil antimicrobial activity
This suggests functional reprogramming of innate cells.
#Macrophages #Neutrophils
🧵3/6
October 2, 2025 at 3:36 PM
🧬 SAS-trained mice showed:
-Reduced proinflammatory TNF production by macrophages
-Increased circulating monocytes and altered HSPC population dynamics
-Enhanced neutrophil antimicrobial activity
This suggests functional reprogramming of innate cells.
#Macrophages #Neutrophils
🧵3/6
-Reduced proinflammatory TNF production by macrophages
-Increased circulating monocytes and altered HSPC population dynamics
-Enhanced neutrophil antimicrobial activity
This suggests functional reprogramming of innate cells.
#Macrophages #Neutrophils
🧵3/6
💉 We used the Sigma Adjuvant System (SAS), which contains MPLA (TLR4 agonist) and TDCM (MINCLE agonist).
We treated mice and tracked long-term changes in bone marrow hematopoietic stem and progenitor cells (HSPCs).
Result: SAS shifted HSPC populations toward myeloid-biased progenitors.
🧵2/6
We treated mice and tracked long-term changes in bone marrow hematopoietic stem and progenitor cells (HSPCs).
Result: SAS shifted HSPC populations toward myeloid-biased progenitors.
🧵2/6
October 2, 2025 at 3:36 PM
💉 We used the Sigma Adjuvant System (SAS), which contains MPLA (TLR4 agonist) and TDCM (MINCLE agonist).
We treated mice and tracked long-term changes in bone marrow hematopoietic stem and progenitor cells (HSPCs).
Result: SAS shifted HSPC populations toward myeloid-biased progenitors.
🧵2/6
We treated mice and tracked long-term changes in bone marrow hematopoietic stem and progenitor cells (HSPCs).
Result: SAS shifted HSPC populations toward myeloid-biased progenitors.
🧵2/6
Muchas gracias a la organización del evento, a Hika Ateneo por el espacio, y a todas aquellas personas que se acercaron a conocer un poco más nuestros proyectos de investigación. ¡Espero que disfrutaran y aprendieran tanto como yo!
¡Nos vemos el año que viene en los bares!
#PINT25ES #PINT25BIO
¡Nos vemos el año que viene en los bares!
#PINT25ES #PINT25BIO
May 22, 2025 at 5:25 AM
Muchas gracias a la organización del evento, a Hika Ateneo por el espacio, y a todas aquellas personas que se acercaron a conocer un poco más nuestros proyectos de investigación. ¡Espero que disfrutaran y aprendieran tanto como yo!
¡Nos vemos el año que viene en los bares!
#PINT25ES #PINT25BIO
¡Nos vemos el año que viene en los bares!
#PINT25ES #PINT25BIO
Esta charla se enmarca dentro de "Pint of Science", un festival internacional de divulgación científica en el que me hace mucha ilusión participar, especialmente siendo el décimo aniversario. ¡Gracias @pintofscience.es y al equipo organizador de Bilbo por la oportunidad!
#PINT25BIO #PINT25ES
#PINT25BIO #PINT25ES
May 14, 2025 at 12:15 PM
Esta charla se enmarca dentro de "Pint of Science", un festival internacional de divulgación científica en el que me hace mucha ilusión participar, especialmente siendo el décimo aniversario. ¡Gracias @pintofscience.es y al equipo organizador de Bilbo por la oportunidad!
#PINT25BIO #PINT25ES
#PINT25BIO #PINT25ES