@aishwaryamagesh.bsky.social
Reposted
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs) that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived IL-13 supports AF function, thus engaging in a pro-allergic dialogue that promotes type 2 immunity.
dlvr.it
December 13, 2025 at 3:38 PM
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Check out latest work from the LuxuriousLajoieLab✨🪿
#Fibroblasts aren’t just structural cells - they actively talk to immune cells. We found that fibro-derived #C3 maintains #ILC2s, while #IL-13 from ILC2s help maintain fibros in #airwayallergy. A bi-directional #crosstalk driving #allergicresponse!
#Fibroblasts aren’t just structural cells - they actively talk to immune cells. We found that fibro-derived #C3 maintains #ILC2s, while #IL-13 from ILC2s help maintain fibros in #airwayallergy. A bi-directional #crosstalk driving #allergicresponse!
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs)
that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived
IL-13 supports AF function...
www.cell.com
December 3, 2025 at 10:57 PM
Check out latest work from the LuxuriousLajoieLab✨🪿
#Fibroblasts aren’t just structural cells - they actively talk to immune cells. We found that fibro-derived #C3 maintains #ILC2s, while #IL-13 from ILC2s help maintain fibros in #airwayallergy. A bi-directional #crosstalk driving #allergicresponse!
#Fibroblasts aren’t just structural cells - they actively talk to immune cells. We found that fibro-derived #C3 maintains #ILC2s, while #IL-13 from ILC2s help maintain fibros in #airwayallergy. A bi-directional #crosstalk driving #allergicresponse!
Reposted
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs)
that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived
IL-13 supports AF function...
www.cell.com
December 3, 2025 at 1:29 AM
New paper alert! We show essential role of #fibroblasts derived #complement C3 in maintaining #Il33-#ILC2 hub during airway #allergy. Congratulations to hard working Ph.D. Students @atakkatan.bsky.social @aishwaryamagesh.bsky.social www.cell.com/cell-reports... @johnshopkinsmmi.bsky.social
Reposted
Enjoying #AAI2025 and learning a bunch of new science with folks from the lab ! #immunology2025
May 4, 2025 at 11:03 PM
Enjoying #AAI2025 and learning a bunch of new science with folks from the lab ! #immunology2025