@ahmad-ayadi.bsky.social
🔬Limiting just one amino acid, methionine, allows our body to gently mend the delicate genetic blueprint of our life. It awakens protectors in the brain while easing the liver's toil, creating a quiet harmony that shields us from time.
pubmed.ncbi.nlm.nih.gov/40723841/
pubmed.ncbi.nlm.nih.gov/40723841/
Methionine Restriction Differentially Modulates Expression of Genes in the Base Excision Repair Pathway in Rat Brain and Liver - PubMed
Methionine restriction (MetR) is a dietary intervention that extends mean and maximum life span in rodents, at least in part, by reducing oxidative stress and promoting DNA stability in different tissues. Regarding DNA stability, DNA repair pathways play a critical role, both in the nuclear and mito …
pubmed.ncbi.nlm.nih.gov
January 11, 2026 at 10:04 AM
🔬Limiting just one amino acid, methionine, allows our body to gently mend the delicate genetic blueprint of our life. It awakens protectors in the brain while easing the liver's toil, creating a quiet harmony that shields us from time.
pubmed.ncbi.nlm.nih.gov/40723841/
pubmed.ncbi.nlm.nih.gov/40723841/
HELLS shields cancer DNA by remodeling chromatin.
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
The chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage
Abstract. The SNF2 family chromatin remodeler HELLS has emerged as an important regulator of cell proliferation, genome stability, and several cancer pathw
academic.oup.com
January 10, 2026 at 11:15 AM
HELLS shields cancer DNA by remodeling chromatin.
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
🎯Targeting LIPT1 triggers a 2HG surge that acts as an epigenetic mask to hide DNA damage. This paralyzes TIP60-ATM signaling and homologous recombination, leaving tumors defenseless against radiation.
Full Study: www.science.org/doi/10.1126/...
Full Study: www.science.org/doi/10.1126/...
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
www.science.org
January 9, 2026 at 10:16 AM
🎯Targeting LIPT1 triggers a 2HG surge that acts as an epigenetic mask to hide DNA damage. This paralyzes TIP60-ATM signaling and homologous recombination, leaving tumors defenseless against radiation.
Full Study: www.science.org/doi/10.1126/...
Full Study: www.science.org/doi/10.1126/...
🧬🧫While healthy stem cells work to mend us, cancer stem cells hijack that healing to build fortresses of resistance. By unmasking their hidden genetic maps, we can finally target the illness while keeping our body's natural healers safe.
pubmed.ncbi.nlm.nih.gov/40868290/
pubmed.ncbi.nlm.nih.gov/40868290/
Transcriptomic Comparisons of Somatic and Cancer Stem Cells - PubMed
Stem cells are essential for tissue maintenance, repair, and regeneration, yet their dysregulation gives rise to cancer stem cells (CSCs), which drive tumor progression, metastasis, and therapy resistance. Despite extensive research on stemness and oncogenesis, a critical gap remains in our understa …
pubmed.ncbi.nlm.nih.gov
January 8, 2026 at 6:02 PM
🧬🧫While healthy stem cells work to mend us, cancer stem cells hijack that healing to build fortresses of resistance. By unmasking their hidden genetic maps, we can finally target the illness while keeping our body's natural healers safe.
pubmed.ncbi.nlm.nih.gov/40868290/
pubmed.ncbi.nlm.nih.gov/40868290/