We identified O-glycosylation of STAT1 (Ser499/Thr510) as critical for maintaining Th1 effector function. Inhibiting O-glycosyltransferase or mutating these sites disrupted STAT1 activity and Th1 differentiation.
Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
T helper (Th) cell lineages are linked to metabolism, but precise mechanisms in human Th1 cells remain unclear. We addressed this question by in vitro stimulation and CRISPR/Cas9-mediated gene editing...
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November 4, 2025 at 9:48 AM
We identified O-glycosylation of STAT1 (Ser499/Thr510) as critical for maintaining Th1 effector function. Inhibiting O-glycosyltransferase or mutating these sites disrupted STAT1 activity and Th1 differentiation.