Ari Firestone
@afirestone.bsky.social
Dad and Scientist
Oncology early discovery @calico
Richmond CA
Oncology early discovery @calico
Richmond CA
Reposted by Ari Firestone
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity - Nature
An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.
www.nature.com
October 4, 2023 at 5:57 PM
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity