Isaac Affum
affum.bsky.social
Isaac Affum
@affum.bsky.social
Let love lead ❤️
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As antibiotic resistance escalates, hydroquinine's potential as a therapeutic agent could revolutionize treatment protocols for MDR Pseudomonas aeruginosa infections, addressing a critical gap in current medical practices.
November 28, 2024 at 2:09 AM
With a Minimum Inhibitory Concentration (MIC) of just 2.50 mg/mL, hydroquinine demonstrates remarkable potency. This low concentration needed to inhibit bacterial growth raises hopes for effective treatments against resistant infections.
November 28, 2024 at 2:09 AM
Notably, hydroquinine exhibits both bacteriostatic and bactericidal effects, making it versatile against various bacterial strains. This dual action is vital in treating infections caused by both sensitive and MDR strains
November 28, 2024 at 2:09 AM
Hydroquinine significantly downregulates key genes (arcA, arcB, arcC, arcD) in the ADI pathway. This gene suppression could lead to innovative treatment strategies and addressing the urgent need for effective treatments against multidrug-resistant infections. #ScientificDiscoveries
November 28, 2024 at 2:09 AM
Ceftazidime is widely used to treat infections caused by resistant bacteria, but its efficacy is diminishing due to antimicrobial resistance. Findings show hydroquinine's partial synergy with ceftazidime, supporting combination therapies novel and providing a powerful option to combat MDR strains.
November 28, 2024 at 2:09 AM
Molecular docking studies reveal hydroquinine's interactions with proteins in the ADI pathway. Using tools like Swiss Dock, researchers have identified potential binding sites, paving the way for targeted therapies against resistant strains.
November 28, 2024 at 2:09 AM
Hydroquinine disrupts the arginine deiminase (ADI) pathway of the bacteria. The ADI pathway is widely distributed, where it is frequently a major source of bacterial energy. By targeting this pathway, hydroquinine may effectively starve the bacteria, leading to their demise. #TargetTherapies
November 28, 2024 at 2:09 AM
Pseudomonas aeruginosa is notorious for its multidrug resistance(MDR) capabilities. Pseudomonas bacteria are in fact a major cause of hospital-acquired infection, with an estimated 10,000 cases each year in the UK alone ↓
pmc.ncbi.nlm.nih.gov/articles
Multidrug-Resistant Pseudomonas aeruginosa: Risk Factors and Clinical Impact
Pseudomonas aeruginosa, a leading nosocomial pathogen, may become multidrug resistant (MDR). Its rate of occurrence, the individual risk factors among affected patients, and the clinical impact of inf...
pmc.ncbi.nlm.nih.gov
November 28, 2024 at 2:09 AM
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November 26, 2024 at 5:35 PM
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November 26, 2024 at 5:35 PM