Alex Federation
afederation.bsky.social
Alex Federation
@afederation.bsky.social
Co-founder, CEO of Talus Bio.

Drugging "undruggable" transcription factors with proteomics #chembio.

Scientist, mountain runner, new dad.

https://readout.substack.com
report: afederation.substack.com/p/regulome-r...

tech access application:https://forms.gle/bCi22VnZqbBD3qQq5
Regulome Reports #1: Fasting
72 hours, no food, and a first-ever glimpse into the global human regulome
afederation.substack.com
July 10, 2025 at 12:14 PM
Now we can finally read it. Full write-up in the comments.

More experiments coming:
- Sleep deprivation (new baby incoming)
- Ultramarathon recovery
- Sauna // ice bath
- Alcohol

What else do you want to see? Follow along. Subscribe for updates. Apply for access to our tech.
July 10, 2025 at 12:14 PM
The answer lives in the regulome. It's your body’s real-time operating system, interpreting the environment and making decisions

It decides how your genome responds to stress, sleep, food, toxins, exercise, and more.
July 10, 2025 at 12:14 PM
Well, why do you sometimes wake up feeling like garbage after eight hours of sleep? Your HRV looks fine. You got your morning sunlight. Your bloodwork is normal. Even your genome doesn't have a glaring mutation.
July 10, 2025 at 12:14 PM
@willfondrie.com cool pre-print extended to more interesting chemical space
January 22, 2025 at 1:53 AM

This update of may also help Bristol-Myers Squibb keep Opdivo on the market longer, as the original drug's patent is likely to be expiring soon.
January 5, 2025 at 4:14 PM
This means treatment is much faster, only 3-5 minutes instead of 30 minutes. This could be more comfortable for patients and eventually allow self-administration at home.
January 5, 2025 at 4:14 PM
Opdivo Qvantig is a new subcutaneous version of the cancer drug Opdivo.

It works the same way as Opdivo, blocking the PD-1 receptor on T cells to help the immune system fight cancer. But, it's given as a shot under the skin instead of an infusion into a vein.
January 5, 2025 at 4:14 PM