Anders Kiib
@aekiib.bsky.social
PhD student in the group of Thomas B. Poulsen at Aarhus University. Chemical biology, chemical probes, and novel electrophiles.
And much more! To prevent this “Bluetorial” from getting too long, I will refer you to the paper. Thank you to all co-authors, without whom the project would not have turned out as it did, and thank you for reading this far! 7/7
January 30, 2025 at 9:16 PM
And much more! To prevent this “Bluetorial” from getting too long, I will refer you to the paper. Thank you to all co-authors, without whom the project would not have turned out as it did, and thank you for reading this far! 7/7
The proteomic profiling (chemrxiv.org/engage/chemr...) showed CHM-II to be highly cysteine-selective, which combined with its small size, gives CHM-II potential as a new covalent reactive group 6/7
January 30, 2025 at 9:16 PM
The proteomic profiling (chemrxiv.org/engage/chemr...) showed CHM-II to be highly cysteine-selective, which combined with its small size, gives CHM-II potential as a new covalent reactive group 6/7
Morphological profiling (cell painting) indicated that CHM-II was the most biologically active of the compounds, while simultaneously revealing strong morphological correlations to dimethyl fumarate and sulforaphane – both of which are known to act in a covalent manner. 4/7
January 30, 2025 at 9:15 PM
Morphological profiling (cell painting) indicated that CHM-II was the most biologically active of the compounds, while simultaneously revealing strong morphological correlations to dimethyl fumarate and sulforaphane – both of which are known to act in a covalent manner. 4/7
The synthesis was conducted by fellow PhD student in the group Thomas Terp Paulsen (who is not on BlueSky), and key steps in the syntheses were selective chlorinations (at C2 and C5) and a Ni-catalyzed reductive cross coupling between an enone, a vinyl bromide, and triethylsilyl chloride 3/7
January 30, 2025 at 9:14 PM
The synthesis was conducted by fellow PhD student in the group Thomas Terp Paulsen (who is not on BlueSky), and key steps in the syntheses were selective chlorinations (at C2 and C5) and a Ni-catalyzed reductive cross coupling between an enone, a vinyl bromide, and triethylsilyl chloride 3/7
I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science!
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
January 30, 2025 at 9:12 PM
I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science!
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7