Thank you so much for this research highlight!! Beautifully done!

I am so very proud of our collective work, and of our message: understanding fundamental biology is essential to the understanding of human disease. Basic science matters!

We found that anti-tumor immunity operates differently within the leptomeningeal space. Surprisingly, this is independent of antigen presentation: Interferon gamma drives maturation of dendritic cells into supporters of NK cell-mediated tumor killing.

This truly massive undertaking was led by an extraordinary postdoc in my laboratory, Jan Remsik, now a PI at the VIB. Our led to analysis of a great many patient samples, transgenic models, and a rich collaboration with my friend and colleague Dana Pe’er.