Adrian Isaacs
LightNews LightNews
banner
adrianisaacs.bsky.social
Adrian Isaacs
@adrianisaacs.bsky.social
300 followers 51 following 14 posts
Investigating FTD and ALS at the UK Dementia Research Institute and UCL Queen Square Institute of Neurology
Posts Replies Media Videos
Reposted by Adrian Isaacs
nicolbirsa.bsky.social
If you are looking for a PhD, are passionate about neurobiology and enjoy microscopy, come and join us for a PhD project on axonal pathophysiology in ALS!

www.findaphd.com/phds/project...
Applications close on Friday 4th July 2025

@mndassoc.bsky.social
@uclqsion.bsky.social
Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London on FindAPhD.com
PhD Project - Axonal pathophysiology in ALS: investigating the role of FUS-ALS mutations in axonal damage and regrowth at University College London, listed on FindAPhD.com
www.findaphd.com
June 15, 2025 at 11:25 AM
Reposted by Adrian Isaacs
dementiaresearcher.bsky.social
Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing and Alzheimer’s, using iPSC models, genomics, and molecular biology @ukdri.ac.uk @dervissalih1.bsky.social Closing date: 26th June

www.dementiaresearcher.nihr.ac.uk/job/research...
Research Fellow: Immune system and Cognitive function
Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing & Alzheimer’s using iPSC models, genomics & molecular biology
www.dementiaresearcher.nihr.ac.uk
May 31, 2025 at 9:38 PM
adrianisaacs.bsky.social
We tagged C9orf72 repeat dipeptides in patient iPSC-neurons and did genetic and small molecule screens with interesting results! Huge effort from many lab members @ukdri.ac.uk‬ @uclqsion.bsky.social and @alzheimersresearchuk.org‬ Drug Discovery Institute at UCL www.sciencedirect.com/science/arti...
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons
Repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-associated non-AUG (RAN) t…
www.sciencedirect.com
May 28, 2025 at 2:29 PM
adrianisaacs.bsky.social
I recenty did a podcast about our work in the lab @ukdri.ac.uk @uclqsion.bsky.social to understand the mechanisms that cause FTD/ALS check it out here: SoundCloud on.soundcloud.com/xs6j9EcMbTRW...
- Apple Podcasts podcasts.apple.com/it/podcast/n...
- Spotify open.spotify.com/episode/7cnY...
Genetic Causes of ALS/FTD with Prof. Isaacs
In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns welcome Professor Adrian Isaacs (UCL), who investigates the molecular and cellular mechanisms under
on.soundcloud.com
April 17, 2025 at 9:31 AM
adrianisaacs.bsky.social
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...
rdcu.be
February 25, 2025 at 1:31 PM
adrianisaacs.bsky.social
Check out our new review of C9orf72 ALS in @thelancetneuro.bsky.social with Sarah Mizielinska, Rosa Rademakers and others! Was fun to co-write but tough to collate such incredible progress into a one article: authors.elsevier.com/c/1ke765FFzL...
February 21, 2025 at 9:56 AM
adrianisaacs.bsky.social
A first description of the C9 repeat iNDI lines is now on bioRxiv, a collaboration from genome engineering through cell biology to facilitate ALS/FTD research @michael-e-ward.bsky.social @jacksonlab.bsky.social @cziscience.bsky.social
www.biorxiv.org/content/10.1...
Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD
Induced pluripotent stem cell (iPSC) models are powerful tools for neurodegenerative disease modelling, as they allow mechanistic studies in a human genetic environment and they can be differentiated ...
www.biorxiv.org
February 11, 2025 at 1:46 PM
adrianisaacs.bsky.social
First post here! Our latest paper showing CRISPR-CasRx can target both sense and antisense C9orf72 repeats is just out! rdcu.be/d5ADQ co-led by @alexcammack.bsky.social @ukdri.bsky.social @uclqsion.bsky.social
Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo
Nature Communications - CRISPR-CasRx effectively reduces ALS- and FTD-causing C9orf72 sense and antisense repeat derived RNAs and proteins in cell lines, patient iPSC-neurons and two independent...
rdcu.be
January 8, 2025 at 11:41 AM