Adrián Gonzalo
@adriangonzalo.bsky.social
Treasuring exceptions at IJPB (INRAE Versailles). Thirsty for genetics, chromosome biology and evolution.
Sooooo well deserved!! Looking forward to learning all the new insights you will provide with your project😻
September 28, 2025 at 10:51 AM
Sooooo well deserved!! Looking forward to learning all the new insights you will provide with your project😻
Maybe holocentric chromosomes? Having centromeres dispersed all over the chromosome prevents loss of acentric fragments after breakage. Am I wrong, @amarques.bsky.social ?
June 18, 2025 at 8:59 PM
Maybe holocentric chromosomes? Having centromeres dispersed all over the chromosome prevents loss of acentric fragments after breakage. Am I wrong, @amarques.bsky.social ?
Very interesting weirdo! Good job and congratulations!
June 18, 2025 at 8:53 PM
Very interesting weirdo! Good job and congratulations!
En espagnol on dit "impulso meiótico" -> "impulsion méiotique"?
June 4, 2025 at 6:10 AM
En espagnol on dit "impulso meiótico" -> "impulsion méiotique"?
Finally, I must thank the other co-authors: Kirsten Bomblies and Aditya Nayak for their essential contributions to this work. It would have not been possible without them!
May 9, 2025 at 6:33 PM
Finally, I must thank the other co-authors: Kirsten Bomblies and Aditya Nayak for their essential contributions to this work. It would have not been possible without them!
Conclusion: we found synapsis dynamics is severely compromised in neo-tetraploids, while in established ones it is more efficient even than diploids, and hybrids display sub-optimal synapsis. The extent of these synapsis defects is correlated with the degree of meiotic instability. 8/8.
May 9, 2025 at 6:33 PM
Conclusion: we found synapsis dynamics is severely compromised in neo-tetraploids, while in established ones it is more efficient even than diploids, and hybrids display sub-optimal synapsis. The extent of these synapsis defects is correlated with the degree of meiotic instability. 8/8.
So, why is it so bad for NEO-4X to have incomplete synapsis? We don’t know but we observed certain (non-linear, probably complex) correlation between the extent of asynapsis and crossover number. Excess of crossovers, we know, is a problem for polyploid meiosis 7/8.
May 9, 2025 at 6:33 PM
So, why is it so bad for NEO-4X to have incomplete synapsis? We don’t know but we observed certain (non-linear, probably complex) correlation between the extent of asynapsis and crossover number. Excess of crossovers, we know, is a problem for polyploid meiosis 7/8.
But why is synapsis so messed up in NEO-4X? We observed defects compatible with problems during earlier stages: less pre-synaptic co-alignments, and slower dynamics elongation of synapsis initiation sites. 6/8.
May 9, 2025 at 6:33 PM
But why is synapsis so messed up in NEO-4X? We observed defects compatible with problems during earlier stages: less pre-synaptic co-alignments, and slower dynamics elongation of synapsis initiation sites. 6/8.
We modeled the initial extent of synapsis, the pace of synapsis completion, and the final extent of asynapsis. This suggested that NEO-4X synapsis progress stalls even before HE10 accumulation begins. In summary: EST-4X > 2X > > HYB-4X >>>>>> NEO-4X. 5/8.
May 9, 2025 at 6:33 PM
We modeled the initial extent of synapsis, the pace of synapsis completion, and the final extent of asynapsis. This suggested that NEO-4X synapsis progress stalls even before HE10 accumulation begins. In summary: EST-4X > 2X > > HYB-4X >>>>>> NEO-4X. 5/8.
Are these defects associated with problems in synapsis progression? We used the dynamics of HEI10 as a “developmental clock”: many small foci at early stages, few bright foci in later stages, to measure how early/late is the completion of synapsis (measured by the disappearance of ASY1). 4/8
May 9, 2025 at 6:33 PM
Are these defects associated with problems in synapsis progression? We used the dynamics of HEI10 as a “developmental clock”: many small foci at early stages, few bright foci in later stages, to measure how early/late is the completion of synapsis (measured by the disappearance of ASY1). 4/8
We analyzed this in Arabidopsis arenosa diploids (2X), newly induced tetraploids (NEO-4X), natural established tetraploids (EST-4X), and hybrids (EST-4X x NEO-4X), which have different levels of meiotic stability: 2X > EST-4X > HYB-4X >> NEO-4X. 3/8
May 9, 2025 at 6:33 PM
We analyzed this in Arabidopsis arenosa diploids (2X), newly induced tetraploids (NEO-4X), natural established tetraploids (EST-4X), and hybrids (EST-4X x NEO-4X), which have different levels of meiotic stability: 2X > EST-4X > HYB-4X >> NEO-4X. 3/8
Pairs of homologous chromosomes need to remain pair-wise associated during early meiosis thanks to the formation of the synaptonemal complex (synapsis) for a normal regulation of meiotic recombination, and fertility. But how messy can synapsis get in polyploids? Can polyploids solve this problem?2/8
May 9, 2025 at 6:33 PM
Pairs of homologous chromosomes need to remain pair-wise associated during early meiosis thanks to the formation of the synaptonemal complex (synapsis) for a normal regulation of meiotic recombination, and fertility. But how messy can synapsis get in polyploids? Can polyploids solve this problem?2/8